05664nam 2201381z- 450 991056648320332120220506(CKB)5680000000037548(oapen)https://directory.doabooks.org/handle/20.500.12854/81036(oapen)doab81036(EXLCZ)99568000000003754820202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIdentification and Characterization of Genetic Components in Autism Spectrum Disorders 2019BaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (256 p.)3-0365-3609-4 3-0365-3610-8 The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.Biology, life sciencesbicsscGenetics (non-medical)bicsscResearch & information: generalbicssc15q11.2 BP1-BP2 microdeletion (Burnside-Butler syndrome)15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndromeAMPA receptorsAmplideXanimal modelASDautismautism candidate genesautism spectrum disorderAutism spectrum disorderautism spectrum disordersautism spectrum disorders (ASD)biological networksBMIBody mass indexcancercase-control association analysiscollapsin response mediator protein 4CYFIP1cytokinedata integrationdevelopmental delaysDNA methylationepigeneticsexpression profilefragile X syndromegene expressiongeneticsgenomicsguanine nucleotide exchange factorgutgut-brain interactionheterogeneity reductionIL-6imprintingintellectual disabilityleaky gutmagnesium transporters and supplementationmaternal immune activationmicemicrobiomemicroRNA- interactionsmolecular functions and processesmonocytemosaicismmotor delaysMS-QMAmulti-omicsnanostringnetwork diffusionneurodevelopmental disorderNIPA1NIPA2NMDA receptorsObesityoverlapping genes and gene profilingOverweightparent-of-origin effectspediatricsPhelan McDermid Syndromephenotype-genotype correlationphenotypes and diseasespostnatal VPA injectionpotential treatment optionsPrader-Willi and Angelman syndromesProSAP2quantitative traitsRNA toxicitySAMsex different phenotypesSHANKstratification by trait severitySTRING-protein-protein interactionsuper-pathwayssynaptic plasticitysynaptotagmin-like protein 4 (SYTL4)SYTL4-protein structureT cell cytokinetrained immunitytransmembrane protein 187 (TMEM187)TUBGCP5 geneswhole-exome sequencingβ-glucanBiology, life sciencesGenetics (non-medical)Research & information: generalButler Merlin Gedt1261076Butler Merlin GothBOOK9910566483203321Identification and Characterization of Genetic Components in Autism Spectrum Disorders 20193037291UNINA