05655nam 2201369z- 450 991056648320332120231214133427.0(CKB)5680000000037548(oapen)https://directory.doabooks.org/handle/20.500.12854/81036(EXLCZ)99568000000003754820202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIdentification and Characterization of Genetic Components in Autism Spectrum Disorders 2019BaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (256 p.)3-0365-3609-4 3-0365-3610-8 The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.Research & information: generalbicsscBiology, life sciencesbicsscGenetics (non-medical)bicsscautism spectrum disorders (ASD)canceroverlapping genes and gene profilingsuper-pathwaysphenotypes and diseasesmolecular functions and processes15q11.2 BP1-BP2 microdeletion (Burnside-Butler) syndromeimprintingparent-of-origin effectsphenotype-genotype correlationautismdevelopmental delaysmotor delaysmicrobiomegutProSAP2Phelan McDermid Syndromegut–brain interactionleaky gutIL-6SHANKcollapsin response mediator protein 4autism spectrum disorderneurodevelopmental disorderwhole-exome sequencinganimal modelsex different phenotypes15q11.2 BP1–BP2 microdeletion (Burnside–Butler syndrome)NIPA1NIPA2CYFIP1TUBGCP5 genesPrader–Willi and Angelman syndromesmagnesium transporters and supplementationpotential treatment optionsintellectual disabilityAMPA receptorsNMDA receptorsguanine nucleotide exchange factorsynaptic plasticityAutism spectrum disorderASDObesityOverweightBody mass indexBMIautism candidate genessynaptotagmin-like protein 4 (SYTL4)transmembrane protein 187 (TMEM187)SYTL4-protein structureSTRING-protein-protein interactionexpression profilemicroRNA- interactionsautism spectrum disordersbiological networksgenomicsmulti-omicsnetwork diffusiondata integrationgeneticsquantitative traitsstratification by trait severityheterogeneity reductioncase-control association analysisfragile X syndromeRNA toxicityDNA methylationmosaicismpediatricsMS-QMAAmplideXcytokinemonocyteβ-glucanT cell cytokinetrained immunitymaternal immune activationepigeneticsmicepostnatal VPA injectionSAMgene expressionnanostringResearch & information: generalBiology, life sciencesGenetics (non-medical)Butler Merlin Gedt1261076Butler Merlin GothBOOK9910566483203321Identification and Characterization of Genetic Components in Autism Spectrum Disorders 20193037291UNINA