03866nam 2201285z- 450 991056648250332120231214133414.0(CKB)5680000000037555(oapen)https://directory.doabooks.org/handle/20.500.12854/81038(EXLCZ)99568000000003755520202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierThe Role of PPARs in DiseaseBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (274 p.)3-0365-3992-1 3-0365-3991-3 This reprint combines recent original manuscripts and reviews covering the multiple functions of peroxisome proliferator-activated receptors in physiology and pathophysiology. Potential applications and limitations of PPAR agonists and antagonists are discussed. All original contributions were published in Cells.MedicinebicsscPhysiologybicsscperoxisome-proliferator activated receptorstumor angiogenesistumor progressionmetastasis formationendothelial cellsRNA sequencingPPARstoxicologypharmacologyligandvascularcoronary arterylipidomicseicosanoidsinflammationCYP450peroxisome proliferator-activated receptorangiogenesisproliferationmetastasisimmortalityresistance to cell deathgrowth suppressorsimmune systemcellular metabolismPPARnuclear receptorsaddictionalcoholnicotineopioidspsychostimulantsanimal modelshuman studiesAlzheimer’srisk factorsPPARαlipidsfatty acidsmodulatorscognitionsextherapyhypertrophic adipocytesPPARG isoformsPPARG splicingdominant-negative isoformin vitro adipocytesadipogenesishypertrophic obesityinsulin-resistanceperoxisome proliferator-activated receptors (PPARs)synthetic agonistsnon-alcoholic fatty liver disease (NAFLD)non-alcoholic steatohepatitis (NASH)fibrosisSirtuin1peroxisome proliferator-activated receptor-γ coactivator-1αperoxisome proliferator activated receptorsobesitymetabolic syndromevitamin B12folatefetal programminginherited metabolic disordersPGC-1α, diseasekidneycancerAKICKDnephronPKDciliacystogenesisligandsAlzheimer’s disease (AD)MedicinePhysiologyWagner Nicoleedt1303406Wagner Kay-DietrichedtWagner NicoleothWagner Kay-DietrichothBOOK9910566482503321The Role of PPARs in Disease3027006UNINA