08184nam 2202329z- 450 991056647600332120220506(CKB)5680000000037619(oapen)https://directory.doabooks.org/handle/20.500.12854/81102(oapen)doab81102(EXLCZ)99568000000003761920202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCreatine Supplementation for Health and Clinical DiseasesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (562 p.)3-0365-2155-0 3-0365-2156-9 Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue.Biology, life sciencesbicsscFood & societybicsscResearch & information: generalbicsscactivated protein kinase (AMPK)adaptive immunityadenosine 5'-monopnophosphate-activated protein kinaseAdenosine mono-phosphate (AMP)adipose tissueamino acidsamyotrophic lateral sclerosisanemiaanthracyclineanthracyclinesanti-inflammatoryanticancerantioxidantathletesathletic performanceatrophybioinformaticsBMI-for-agebrain injurycachexiacancer immunotherapycardiac infarctioncardiac signalingcardiac toxicitycardiopulmonary diseasecardiotoxicitycardiovascular diseasecell survivalcellular allostasiscellular metabolismchildrenchronic fatiguechronic fatigue syndromeclinical trialcognitioncognitive impairmentconcussioncreatinecreatine kinasecreatine kinase (CK)creatine perfusioncreatine supplementationcreatine synthesis deficienciescreatine transportercreatine transporter (CrT)Crohn's diseasecytotoxic T cellsdepressiondevelopmentdiabetesdietary ingredientsdietary supplementdietary supplementsdoxorubicindynamic biosensorenergy metabolismergogenic aidergogenic aidsexerciseexercise performancefemalefertilityfrailtyGAAglucose transporter (GLUT)glycemic controlgrowthheartheart failureheighthemodialysishormoneshyperhomocysteinemiahypertrophyhypoxiaimmobilizationimmunityinflammationinflammatory bowel diseases (IBD)innate immunityintestinal epithelial cell protectionintestinal tissue protectionintradialytic creatine supplementationischemialiver kinase B1 (LKB1)long COVIDmacrophage polarizationMAP kinase signaling systemMCDAmenopausemenstrual cyclemetabolic regulatormethylationmitochondriamitochondrial cytopathymitochondrial permeability transition pore (mPTP)mitochondriopathiamoodmusclemuscle atrophymuscle damagemuscle fatiguemuscle strengthmuscle weaknessmuscular adaptationmuscular dystrophymuscular powermyocardial infarctionneurodegenerative diseasesneuromodulationnewbornnoncommunicable diseasenutritional supplementsorgan transplantationosteoporosisosteosarcopeniaoxidative stressParkinson's Diseaseperformancephosphagensphosphocreatinephosphocreatine (PCr)phosphorylcreatinephysiological adaptationpleiotropic effects of creatine (Cr) supplementationpost-viral fatigue syndromepregnancyprotein energy wastingreactive oxygen species (ROS)recoveryrehabilitationresistance exerciseresistance trainingsarcopeniasignal transductionskeletal musclesodium-chloride-dependent neurotransmitter symporterssoyspinal cord injurysports nutritionstature-for-agestrengthstrokesupplementationsupplementssystems biologyT cell antitumor immunitythermogenesistoll-like receptorstoxicitytrainingtraumatic brain injurytreatmenttype 2 diabetes mellitusulcerative colitisvascular healthvascular pathologyvegetarian/vegan dietweightliftingyouthBiology, life sciencesFood & societyResearch & information: generalKreider Richard Bedt1303402Stout JeffreyedtKreider Richard BothStout JeffreyothBOOK9910566476003321Creatine Supplementation for Health and Clinical Diseases3027001UNINA