08173nam 2202317z- 450 991056647600332120231214133517.0(CKB)5680000000037619(oapen)https://directory.doabooks.org/handle/20.500.12854/81102(EXLCZ)99568000000003761920202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCreatine Supplementation for Health and Clinical DiseasesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (562 p.)3-0365-2155-0 3-0365-2156-9 Creatine plays a critical role in cellular metabolism, primarily by binding with phosphate to form phosphocreatine (PCr) as well as shuttling high-energy phosphate compounds in and out of the mitochondria for metabolism. Increasing the dietary availability of creatine increases the tissue and cellular availability of PCr, and thereby enhances the ability to maintain high-energy states during intense exercise. For this reason, creatine monohydrate has been extensively studied as an ergogenic aid for exercise, training, and sport. Limitations in the ability to synthesize creatine and transport and/or store dietary creatine can impair metabolism and is a contributor to several disease states. Additionally, creatine provides an important source of energy during metabolically stressed states, particularly when oxygen availability is limited. Thus, researchers have assessed the role of creatine supplementation on health throughout the lifespan, as well as whether creatine availability may improve disease management and/or therapeutic outcomes. This book provides a comprehensive overview of scientific and medical evidence related to creatine's role in metabolism, health throughout the lifespan, and our current understanding of how creatine can promote brain, heart, vascular and immune health; reduce the severity of musculoskeletal and brain injury; and may provide therapeutic benefits in glucose management and diabetes, cancer therapy, inflammatory bowel disease, and post-viral fatigue.Research & information: generalbicsscBiology, life sciencesbicsscFood & societybicsscergogenic aidscellular metabolismphosphagenssarcopeniacognitiondiabetescreatine synthesis deficienciesconcussiontraumatic brain injuryspinal cord injurymuscle atrophyrehabilitationpregnancyimmunityanti-inflammatoryantioxidantanticancercreatinenutritional supplementsfertilitynewborndevelopmentbrain injurypost-viral fatigue syndromechronic fatigue syndromeGAAcreatine kinasedietary supplementsexerciseskeletal muscleglycemic controltype 2 diabetes mellitusphosphorylcreatinedietary supplementergogenic aidyouthathletesosteoporosisosteosarcopeniafrailtycachexiainnate immunityadaptive immunityinflammationmacrophage polarizationcytotoxic T cellstoll-like receptorsvascular pathologycardiovascular diseaseoxidative stressvascular healthfemalemenstrual cyclehormonesexercise performancemenopausemoodchildrenheightBMI-for-agestature-for-agegrowthphosphocreatinecreatine transportersupplementationtreatmentheartheart failureischemiamyocardial infarctionanthracyclinecardiac toxicityenergy metabolismcell survivalbioinformaticssystems biologycellular allostasisdynamic biosensorpleiotropic effects of creatine (Cr) supplementationinflammatory bowel diseases (IBD)ulcerative colitisCrohn’s diseasecreatine kinase (CK)phosphocreatine (PCr)creatine transporter (CrT)intestinal epithelial cell protectionintestinal tissue protectioncreatine perfusionorgan transplantationAdenosine mono-phosphate (AMP)activated protein kinase (AMPK)liver kinase B1 (LKB1)mitochondrial permeability transition pore (mPTP)reactive oxygen species (ROS)glucose transporter (GLUT)T cell antitumor immunitymetabolic regulatorcancer immunotherapysupplementsmuscle damagerecoveryimmobilizationatrophymuscular dystrophyamyotrophic lateral sclerosisParkinson’s Diseasecardiopulmonary diseasemitochondrial cytopathyhypertrophyathletic performanceweightliftingresistance exercisetrainingmuscular powermuscular adaptationmuscle fatigueadipose tissuemuscle strengthphysiological adaptationmitochondriathermogenesisMAP kinase signaling systemsodium-chloride-dependent neurotransmitter symporterssignal transductionintradialytic creatine supplementationhemodialysismuscleprotein energy wastingclinical trialmuscle weaknesschronic fatiguecognitive impairmentdepressionanemiaresistance trainingsports nutritionstrengthtoxicitymethylationhyperhomocysteinemianeuromodulationMCDAmitochondriopathiacardiac infarctionlong COVIDhypoxiastrokeneurodegenerative diseasesnoncommunicable diseaseadenosine 5′-monopnophosphate-activated protein kinaseanthracyclinescreatine supplementationcardiac signalingcardiotoxicitydoxorubicinsoyvegetarian/vegan dietamino acidsdietary ingredientsperformanceResearch & information: generalBiology, life sciencesFood & societyKreider Richard Bedt1303402Stout JeffreyedtKreider Richard BothStout JeffreyothBOOK9910566476003321Creatine Supplementation for Health and Clinical Diseases3027001UNINA