03332nam 2200709z- 450 991056647530332120220506(CKB)5680000000037626(oapen)https://directory.doabooks.org/handle/20.500.12854/81094(oapen)doab81094(EXLCZ)99568000000003762620202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Advances in MelanomaBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (148 p.)3-0365-3453-9 3-0365-3454-7 Melanoma is a very aggressive tumor which is derived from the transformation of pigment-producing cells termed the melanocytes. This cancer type accounts for most of the deaths associated with skin cancer as well as its incidence and is in constant evolution. Because of the rapid and very high metastatic potential of this tumor, melanoma prognosis has been quite poor for a long time. In the past decade, groundbreaking discoveries in the melanoma research field have led to the development of two main treatment strategies: combination therapies targeting specific kinases or combination therapies focused on immune checkpoint inhibitors (ICIs). These treatment approaches have become the standard of care in most cancer centers and significantly improved the prognosis and overall survival of advanced melanoma patients. Nevertheless, many patients do not benefit from or even respond to these treatments. It is therefore essential to better comprehend the phenomenon of drug resistance, immune escape mechanisms, as well as to search for alternative treatment strategies. In addition, strong predictive biomarkers are desperately needed to improve clinical efficacy. The aim of this Special Issue is to present recent advances in the field of melanoma research, in which the abovementioned areas represent the primary focus, and other relevant themes are also discussed.Public health and preventive medicinebicsscanimal modelsBRAFdruggable mutationsembryogenesisepidemiologyimmune escapeincidencelungmelanoblastmelanoblastsmelanomametastasismicemicroRNAmiRNAsNF1NGS assaypopulation-based studypseudotime analysisreal-time PCRRNAseqsingle-cell transcriptome sequencingskin cancerSpaintargeted therapiestranscriptometransporter associated with antigen processingtreatmenttreatment responseTrp-1ubiquitinationPublic health and preventive medicineLarribère Lioneledt1314110Larribère LionelothBOOK9910566475303321New Advances in Melanoma3031717UNINA