04059nam 2200889z- 450 991056647280332120231214133051.0(CKB)5680000000037652(oapen)https://directory.doabooks.org/handle/20.500.12854/81136(EXLCZ)99568000000003765220202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierUpdate on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet NeedsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (168 p.)3-0365-3433-4 3-0365-3434-2 Azoospermia, defined as the absence of sperm in the ejaculate after examination of the centrifuged specimens, affects about 1% of the male population and 10–15% of infertile men. In about two-thirds of cases, this is caused by severe spermatogenic dysfunction, and it is commonly termed “nonobstructive azoospermia” (NOA) to differentiate it from the less severe form of azoospermia caused by the obstruction of the seminal tract (obstructive azoospermia—OA), the latter affecting the remaining one-third of cases. Managing patients with NOA is challenging due to the severity of spermatogenic dysfunction and the lack of medical treatments, with surgical retrieval of testicular sperm being the only way of enabling some of these patients to father their own biological children. In-depth clinical knowledge is key for supporting clinical reasoning and decision making when counselling patients with NOA, and surgical skill is required to maximize the outcome of surgical procedures that aim to retrieve testicular sperm. The present book is a collection of scientific papers published in a Special Issue of the Journal of Clinical Medicine, authored by some of the most influential researchers in the field. The Special Issue, and thus also this book, were conceived to provide early career reproductive urologists and endocrinologists with an update of the scientific evidence in the field, together with surgical tips.Update on the Management of Non-Obstructive AzoospermiaMedicinebicsscPharmacologybicsscnonobstructive azoospermiamicro-TESEFSH treatmenthormonal treatmenttestosterone levelmicrodissection testicular sperm extractionnon-obstructive azoospermiamanagementinfertilityintracytoplasmic sperm injectiontesticular azoospermiasperm selectionspermcryopreservationin vitro maturationazoospermiadiagnosismale infertilityspermatogenic failuretestis biopsysperm retrievalgenetic testingendocrine evaluationreviewhypogonadismSertoli cell-only syndrometesticular spermatozoaprocessingmicrofluidicsnew technologiesgeneticsexomeWESY chromosomecancerNOAgenesgeneral healthICSIoffspring healthmicroTESEprediction modelMedicinePharmacologyColpi Giovanni Medt1327936Caroppo EttoreedtColpi Giovanni MothCaroppo EttoreothBOOK9910566472803321Update on the Management of Non-Obstructive Azoospermia: Current Evidence and Unmet Needs3038297UNINA