04445nam 2200973z- 450 991056646690332120231214133420.0(CKB)5680000000037711(oapen)https://directory.doabooks.org/handle/20.500.12854/81215(EXLCZ)99568000000003771120202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMethod Development and Applications for Reduced-Risk Products in Separation ScienceBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (154 p.)3-0365-3637-X 3-0365-3638-8 In recent years, there has been rapid growth in the availability of innovative, non-combustible products, including oral tobacco-derived nicotine (OTDN) products, heated tobacco products (HTPs), and electronic cigarettes (also referred to as e-vapor products; EVPs). Industry, academic, and government researchers are developing and validating analytical methods to extract, separate, identify, and quantitate a variety of analytes from these innovative tobacco products using a wide range of analytical techniques. These analytes include constituents such as nicotine, degradants and impurities, flavors, non-tobacco ingredients, HPHCs, and other currently unknown constituents. In this Special Issue, we received nine contributions that covered the latest analytical methods that have been developed and applied for the chemical characterization or exposure assessment to tobacco product constituents of innovative non-combustible products. This Special Issue is representative of the importance of analytical sciences research in characterizing innovative non-combustible products for guiding product design, determining relative product performance, ensuring consistency during the manufacturing process, informing toxicological risk assessment, and enabling regulatory reporting. The current advances in the development and applications of the analytical methods reported in this Special Issue can be used to inform the harm reduction potential of innovative non-combustible products for adult smokers.Research & information: generalbicsscChemistrybicsscAnalytical chemistrybicsscon!® nicotine pouchesnicotinedissolutionrelease profilevalidationproduct assessmentsmokeless tobacco productnicotine degradantsnicotine-related impuritiesalkaloidsnicotine degradation productsnicotine pouchesreduced-risk productsconstituentsmethod developmentmethod validationJUULaerosolnon-targeted analysischemical characterizationENDSe-cigaretteGC-MSLC-HRMSe-liquid2,4-DNPH derivatizationformaldehyde"hidden formaldehyde"formaldehyde-containing hemiacetal/acetal adductsHPHCGC-MS3-hydroxybenzo[a]pyreneLC-MS/MSurinehuman biomonitoringderivatizationpotentially reduced-risk productspropylene glycolelectronic cigarettebiomarker of exposurecompliance markeroral tobacco derived nicotine (OTDN) pouchessnusnicotine releasenicotine dissolutionnicotine extractionequivalencemodern oral nicotine productsHPHCsproduct characterizationsResearch & information: generalChemistryAnalytical chemistryAldeek Fadiedt1332382Aldeek FadiothBOOK9910566466903321Method Development and Applications for Reduced-Risk Products in Separation Science3040915UNINA