06078nam 2201825z- 450 991056646530332120231214133342.0(CKB)5680000000037727(oapen)https://directory.doabooks.org/handle/20.500.12854/80949(EXLCZ)99568000000003772720202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitochondrial Transport ProteinsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (476 p.)3-0365-3410-5 3-0365-3409-1 Mitochondrial transporters are membrane-inserted proteins which provide a link between metabolic reactions occurring within the mitochondrial matrix and outside the organelles by catalyzing the translocation of numerous solutes across the mitochondrial membrane. They include the mitochondrial carrier family members, the proteins involved in pyruvate transport, ABC transporters and channels, and are, therefore, essential for many biological processes and cell homeostasis. Identification and functional studies of many mitochondrial transporters have been performed over the years using both in vitro and in vivo systems. The few recently solved structures of these transporters have paved the way for further investigations. Furthermore, alterations in their function are responsible for several diseases.Research & information: generalbicsscBiology, life sciencesbicsschypoxiaresistance to hypoxiamitochondriamitochondrial calcium transportmitochondrial calcium uniporter complexmitochondrial Ca2+-induced permeability transition porecyclophilin DATP synthasediseaseerror of metabolismmitochondrial carriermitochondrial carrier diseasemitochondrial diseasemitochondrial transportermembrane transportmutationSLC25.mitochondrial permeability transitionapoptosisnecrosisischemia/reperfusioncancerneurodegenerationcyclosporin Ametabolite transportmitochondrial pyruvate carriersideroflexinTOMTIM chaperonesTIM22protein translocationmitochondrial biogenesisamino acidbiological functionioninner mitochondrial membranemitochondrial carrier familyorganic acidsubstrate specificitytransport mechanismvitaminUSMG5/DAPITglucose-stimulated insulin secretionglucose-induced expressionmembrane subunits of ATP synthaseATP synthase oligomers mitochondrial cristae morphologymetabolismmetabolic disordersadult-onset type II citrullinemia (CTLN2)aspartate/glutamate carrier (AGC)animal modelargininosuccinate synthetase (ASS)aversion to carbohydratescitrinfood tasteneonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)protein–protein interactionMPClifespanpyruvate metabolismmitochondrial transportperoxisomescarriercofactorABC transporteraquaporinion channelspotassium channelsATPcalciumROSpotassium channel openersMCFfunctionplant metabolismplant developmentdiseasesVDAC1viruspancreatic isletsβ-celldiabetesglucotoxicityglucolipotoxicitylipotoxicitymitochondrial carriersSLC transportersSLC25SLC54SLC55LETMSLC56sequence analysisprotein targetingVoltage-Dependent Anion selective Channelisoformsoxidative post-translational modificationgene promoteryeastbioenergeticsSLC25A1CICCTPcitrateinflammation22.q11.2NAFLD/NASHcarnitinecarnitine acyl-carnitine carriercarnitine acyl-carnitine translocasepost-translational modificationsolute carrier family 25SLC25A20MCUmitochondrial Ca2+ uniporterCa2+ signalingmitochondrial metabolismskeletal muscle mitochondriaSLC25A51NAD+ transportersNADelectrophysiologyATP-dependent potassium channelResearch & information: generalBiology, life sciencesPalmieri Ferdinandoedt91413Palmieri FerdinandoothBOOK9910566465303321Mitochondrial Transport Proteins3037213UNINA