06097nam 2201837z- 450 991056646530332120220506(CKB)5680000000037727(oapen)https://directory.doabooks.org/handle/20.500.12854/80949(oapen)doab80949(EXLCZ)99568000000003772720202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitochondrial Transport ProteinsBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (476 p.)3-0365-3410-5 3-0365-3409-1 Mitochondrial transporters are membrane-inserted proteins which provide a link between metabolic reactions occurring within the mitochondrial matrix and outside the organelles by catalyzing the translocation of numerous solutes across the mitochondrial membrane. They include the mitochondrial carrier family members, the proteins involved in pyruvate transport, ABC transporters and channels, and are, therefore, essential for many biological processes and cell homeostasis. Identification and functional studies of many mitochondrial transporters have been performed over the years using both in vitro and in vivo systems. The few recently solved structures of these transporters have paved the way for further investigations. Furthermore, alterations in their function are responsible for several diseases.Biology, life sciencesbicsscResearch and information: generalbicssc22.q11.2ABC transporteradult-onset type II citrullinemia (CTLN2)amino acidanimal modelapoptosisaquaporinargininosuccinate synthetase (ASS)aspartate/glutamate carrier (AGC)ATPATP synthaseATP synthase oligomers mitochondrial cristae morphologyATP-dependent potassium channelaversion to carbohydratesbioenergeticsbiological functionCa2+ signalingcalciumcancercarnitinecarnitine acyl-carnitine carriercarnitine acyl-carnitine translocasecarrierCICcitratecitrincofactorCTPcyclophilin Dcyclosporin Adiabetesdiseasediseaseselectrophysiologyerror of metabolismfood tastefunctiongene promoterglucolipotoxicityglucose-induced expressionglucose-stimulated insulin secretionglucotoxicityhypoxiainflammationinner mitochondrial membraneionion channelsischemia/reperfusionisoformsLETMlifespanlipotoxicityMCFMCUmembrane subunits of ATP synthasemembrane transportmetabolic disordersmetabolismmetabolite transportmitochondriamitochondrial biogenesismitochondrial Ca2+ uniportermitochondrial Ca2+-induced permeability transition poremitochondrial calcium transportmitochondrial calcium uniporter complexmitochondrial carriermitochondrial carrier diseasemitochondrial carrier familymitochondrial carriersmitochondrial diseasemitochondrial metabolismmitochondrial permeability transitionmitochondrial pyruvate carriermitochondrial transportmitochondrial transporterMPCmutationNADNAD+ transportersNAFLD/NASHnecrosisneonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)neurodegenerationorganic acidoxidative post-translational modificationpancreatic isletsperoxisomesplant developmentplant metabolismpost-translational modificationpotassium channel openerspotassium channelsprotein targetingprotein translocationprotein-protein interactionpyruvate metabolismresistance to hypoxiaROSsequence analysissideroflexinskeletal muscle mitochondriaSLC transportersSLC25SLC25.SLC25A1SLC25A20SLC25A51SLC54SLC55SLC56solute carrier family 25substrate specificityTIM chaperonesTIM22TOMtransport mechanismUSMG5/DAPITVDAC1virusvitaminVoltage-Dependent Anion selective Channelyeastβ-cellBiology, life sciencesResearch and information: generalPalmieri Ferdinandoedt91413Palmieri FerdinandoothBOOK9910566465303321Mitochondrial Transport Proteins3037213UNINA