05531nam 2201309z- 450 991056646260332120220506(CKB)5680000000037755(oapen)https://directory.doabooks.org/handle/20.500.12854/81051(oapen)doab81051(EXLCZ)99568000000003775520202205d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRegional Intestinal Drug AbsorptionBiopharmaceutics and Drug FormulationBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (238 p.)3-0365-3658-2 3-0365-3657-4 The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.Regional Intestinal Drug Absorption Manufacturing industriesbicsscMedicine and Nursingbicsscabsorption-modifying excipientsBCS class IV drugsBCS drugsbioequivalencebiomimetic membranebiopharmaceuticsbiopharmaceutics classification systemBiopharmaceutics Classification Systemclinical studiescolon absorptioncombined zero- and first-order absorptioncontrolled release drug productDDIdisintegrationdissolutiondissolution testdrug absorptiondrug permeabilitydrug solubilitydrug solubility/dissolutiondrug-drug interactionsenergy intakeenteric-coatedfirst-order absorptionfirst-pass effectFranz cellFranz-PAMPAfurosemidegastrointestinalgastrointestinal hormoneGastroPlushierarchical support vector regression (HSVR)human colon carcinoma cell layer (Caco-2)ibuprofenICHin silico modelingin situ perfusionin vitroin vitro in vivo extrapolationsintestinal absorptionintestinal perfusionintestinal permeabilityIVIVElocation-dependent absorptionmanometrymechanistic modelingmicrodevicesmucoadhesionnutrient absorptionnutrient digestionobesityoral absorptionoral drug deliveryoral peptide deliverypassive drug transportPBBMPBPKpermeation enhancerspharmaceutical developmentpharmacokineticsPhoenix WinNonlinphysiologically-based pharmacokinetic (PBPK) modelingpostprandial glycaemiapravastatinquality controlregion of the gutregional intestinal permeabilityregional/segmental-dependent permeability and absorptionroute-dependent intestinal metabolismsegmental-dependent intestinal permeabilitysegregated flow intestinal model (SFM)shapetraditional model (TM)transit compartment absorption modeltype 2 diabeteszero-order absorptionManufacturing industriesMedicine and NursingGonzalez-Alvarez Maria Isabeledt1330868Dahan ArikedtGonzalez-Alvarez Maria IsabelothDahan ArikothBOOK9910566462603321Regional Intestinal Drug Absorption3040001UNINA