03985nam 22007575 450 991055939340332120240408144856.09783030940041(electronic bk.)978303094003410.1007/978-3-030-94004-1(MiAaPQ)EBC6946348(Au-PeEL)EBL6946348(CKB)21469055700041(DE-He213)978-3-030-94004-1(PPN)262167964(EXLCZ)992146905570004120220405d2022 u| 0engurcnu||||||||txtrdacontentcrdamediacrrdacarrierMacropinocytosis Functions and Mechanisms /edited by Cosimo Commisso1st ed. 2022.Cham :Springer International Publishing :Imprint: Springer,2022.1 online resource (227 pages)Subcellular Biochemistry,2542-8810 ;98Includes index.Print version: Commisso, Cosimo Macropinocytosis Cham : Springer International Publishing AG,c2022 9783030940034 Part 1: Functions of Macropinocytosis -- Chapter 1: Functional Diversity of Macropinocytosis -- Chapter 2: Macropinocytosis and Cancer: From Tumor Stress to Signaling Pathways -- Chapter 3: The amoebal model for micropinocytosis -- Chapter 4: Extracellular ATP and macropinocytosis -- Chapter 5: Macropinocytosis and Cell Migration: Don't drink an drive -- Chapter 6: Macropinocytosis in phagocyte function and immunity -- Part 2: Signaling Mechanisms Driving Macropinocytosis -- Chapter 7: Roles of 3' Phosphoinositides in Macropinocytosis -- Chapter 8: Signaling pathways that regulate macropinocytosis in mammalian cells -- Chapter 9: Wnt, GSK3 and Macropinocytosis -- Chapter 10: Kras addiction promotes cancer cell adapation in harsh microenvironment through micropinocytosis -- Chapter 11: Kras-independent macropinocytosis in pancreatic cancer.This book presents the functions and mechanisms of macropinocytosis, an actin-driven endocytic uptake process. Key points, including the evolutionary origins of macropinocytosis and major signaling pathways that regulate this uptake mechanism, are highlighted. A wide-array of functions of macropinocytosis are described, including cellular metabolism, cell death, cell migration and antigen presentation. Macropinocytosis has recently been recognized as a critical pathway in disease pathology and treatment. Therefore, a broad overview of macropinocytosis will benefit clinicians, as well as translational and basic research scientists. Moreover, as one of the main clathrin-independent endocytic routes, compiling all the critical information about macropinocytosis in one collection, this book will also be helpful to educators and their students.Subcellular Biochemistry,2542-8810 ;98CytologyBiophysicsCell interactionBiological transportCell membranesMedicineResearchBiologyResearchCell BiologyMechanobiological Cell SignalingMembrane TraffickingBiomedical ResearchCitologiathubLlibres electrònicsthubCytology.Biophysics.Cell interaction.Biological transport.Cell membranes.MedicineResearch.BiologyResearch.Cell Biology.Mechanobiological Cell Signaling.Membrane Trafficking.Biomedical Research.Citologia571.6571.6Commisso CosimoMiAaPQMiAaPQMiAaPQ9910559393403321Macropinocytosis2832663UNINA