05232nam 2201513z- 450 991055780030332120210501(CKB)5400000000045400(oapen)https://directory.doabooks.org/handle/20.500.12854/68544(oapen)doab68544(EXLCZ)99540000000004540020202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierEmerging Role of Lipids in Metabolism and DiseaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (308 p.)3-03943-701-1 3-03943-702-X Even though initially considered as a passive means for storing energy, lipids are now regarded as multifaceted molecules with crucial structural and functional activities. For instance, some of them play essential roles as key components of cell membranes whereas others act as signaling molecules in the regulation of cell homeostasis. In recent years, lipid research has attracted increasing interest because of the involvement of this class of compounds in human health. Indeed, a plethora of pathological conditions are characterized by alterations in lipid metabolism, such as cardiovascular diseases and brain disorders. This Special Issue is a collection of papers from different experts in lipid research, with the aim of providing new insights into the physiopathological involvement of lipids and their impact on human health. This collection also demonstrates the usefulness of interdisciplinary approaches in the development of novel methods to study and manipulate lipid metabolism, which may represent an attractive target for designing effective therapeutic strategies to counteract numerous pathologies.Medicinebicsscacid sphingomyelinaseadiponectinadipose tissueangiogenesisatherosclerosisATMautotaxinBDNFBET proteinsbrainbreast cancerbreast reconstructioncardiovascular diseasecell proliferationcell signalingcholesterolCholesterolchronic inflammationdiabetes mellitusDNA damage responsedouble strand breakseicosanoidsendothelial cellepicardial fat thicknessepigeneticsepinephrinefatty acidFatty acidsfemalefrontal cortexG-protein coupled receptorsgenderglyceridehaptoglobinhigh-cholesterol diethigh-density lipoproteinhigh-sensitivity c-reactive proteinhippocampusHMGCRhyperglycemiaionizing radiationischemiaischemic strokeJQ1LDLrleptinlipidlipid dropletslipid mediatorsLipid mediatorslipid metabolismlipid metabolism diseaseslipid storage diseasesLipidslipocalinlipolysislipophagyLipophagylipoproteinsliverlysocardiolipin acyltransferaselysophosphatidic acidmetabolic reprogrammingmetabolic stressmetabolismmTORC1mutationsneutral sphingomyelinasenuclear sphingolipidsoral drug absorptionoxidative stressoxidized phospholipidsp53pathologyphosphatidylinositol 4,5-bisphosphatephospholipase A2 (PLA2)phospholipase Cphospholipase Dphospholipidpolyunsaturated fatty acidsprodrugprostaglandinspulmonary fibrosisradiationSODsphingolipidsSphingolipidssphingomyelin metabolismsphingosine kinase 1sphingosine-1-phosphateSREBPsteroidsynaptic proteinsTFEBTMEM97visceral fat thicknessMedicinePallottini Valentinaedt1309613Segatto MarcoedtPallottini ValentinaothSegatto MarcoothBOOK9910557800303321Emerging Role of Lipids in Metabolism and Disease3029453UNINA