06241nam 2201777z- 450 991055779350332120210501(CKB)5400000000045453(oapen)https://directory.doabooks.org/handle/20.500.12854/68695(oapen)doab68695(EXLCZ)99540000000004545320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular PsychiatryBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (288 p.)3-03936-120-1 3-03936-121-X The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders.Medicine and NursingbicsscMental health servicesbicssc(2R,6R)-Hydroxynorketamine5-HT 4 receptor5-HT4Racid sphingomyelinaseactin dynamicsaffective temperamentalcohol dependencealpha-synucleinAlzheimer's diseaseantidepressantantidepressant treatmentantidepressantsantipsychoticsbasic-helix-loop-helixBDNFbehaviorbiomarker discoverybiomarkersbipolar disorderbraincardiovascular diseasecell adhesion moleculeschemokineschildhood-onset schizophrenia (COS)circadian rhythmscoactivatorcognitioncopy number variation (CNV)cordanceCRMP-2CyP40cytoskeletondendritic arborizationdepressionDISC1DNA methylationdopaminergic gene polymorphismsDRR1drug designearly neurodevelopmentelectroconvulsive therapyendocrinologyexpressionFAM107AFKBP5FKBP51FKBP52forced swimminggendergene expressiongeneral cognitive functiongenetic correlationglucocorticoidsGRGWASHamilton Scale of DepressionhippocampusHPA axisHsp90Immune responseimmunohistochemistryimmunologyinduced pluripotent stem cell (iPSC)inflammationintelligenceKetamineliver enzymesmachine learningmajor depressionmajor depressive disordermineralocorticoid receptor knockoutmiRNAsmolecular chaperonesmood disordermulti-target drugsmulti-task learningn/anervous systemneurodevelopmentneuroinflammationneuronal differentiationobesityParkinson's diseasepolypharmacologyPP5PPARγproteomicsPSA-NCAMpsychiatric diseasepsychiatryrapid-actingresilienceresponse variabilityRoman rat linesschizophreniaserotoninsex differencesleepsleep EEGSNCAsocial defeatsphingolipid metabolismsteroid hormonesstressstress physiologystress responsesusceptibilitysynapseT cellsTh17 cellstranscription biologyTreg cellstrkBTU3Awestern blotwithdrawalMedicine and NursingMental health servicesRein Theoedt1280404Fries Gabriel RedtRein TheoothFries Gabriel RothBOOK9910557793503321Molecular Psychiatry3016893UNINA