06180nam 2201753z- 450 991055779350332120231214133638.0(CKB)5400000000045453(oapen)https://directory.doabooks.org/handle/20.500.12854/68695(EXLCZ)99540000000004545320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMolecular PsychiatryBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (288 p.)3-03936-120-1 3-03936-121-X The book highlights important aspects of Molecular Psychiatry, including molecular mechanisms, animal models, biomarkers, advanced methods, drugs and antidepressant response, as well as genetics and epigenetics. Molecular mechanisms are a vital part of the search for the biological basis of psychiatric disorders, providing molecular hints that can later be tested as biomarkers or targets for drug development. Animal models represent a commonly used approach to aid in this bench-to-bed translation; the examples here are social defeat stress and the Roman High-Avoidance (RHA) and the Roman Low-Avoidance (RLA) rats. For biomarkers, psychiatric disorders pose a particular challenge due to the tissue specificity of many currently investigated biomarkers; i.e., not all blood-based measures directly represent changes in the brain. The Ebook includes five articles focused on the challenges of identifying clinically and biologically relevant biomarkers for psychiatric disorders. Scientific progress typically is fostered by the development of new methods. The application of machine learning methods for the proper analysis of Big Data and induced pluripotent stem cells are examples outlined in this Ebook. Furthermore, three articles are devoted to the understanding of the mechanisms of actions of existing drugs with the ultimate goal of identifying ways to predict treatment response in patients. Finally, three articles deepen the insight into the genetics and epigenetics of psychiatric disorders.MedicinebicsscMental health servicesbicssccardiovascular diseasecell adhesion moleculesimmunologyinflammationnervous systemschizophreniabipolar disordermajor depressive disorderDNA methylationresponse variabilityantipsychoticsdrug designmulti-target drugspolypharmacologymulti-task learningmachine learningbiomarker discoverypsychiatryserotonin5-HT 4 receptor5-HT4Rdepressionmood disorderexpressionAlzheimer's diseasecognitionParkinson's diseaseforced swimmingRoman rat linesstresshippocampusBDNFtrkBPSA-NCAMwestern blotimmunohistochemistrygeneral cognitive functionintelligenceGWASgenetic correlationchildhood-onset schizophrenia (COS)induced pluripotent stem cell (iPSC)copy number variation (CNV)early neurodevelopmentneuronal differentiationsynapsedendritic arborizationmiRNAsstress physiologycytoskeletonactin dynamicsDRR1TU3AFAM107Aacid sphingomyelinasealcohol dependenceliver enzymessphingolipid metabolismwithdrawalHsp90GRstress responsesteroid hormonesmolecular chaperonespsychiatric diseasecircadian rhythmsFKBP51FKBP52CyP40PP5DISC1neurodevelopmentCRMP-2proteomicsantidepressant treatmentHPA axisgene expressionFKBP5sleepsleep EEGbiomarkersantidepressantscordancegendersex differenceantidepressantrapid-actingKetamineendocrinology(2R,6R)-Hydroxynorketamineelectroconvulsive therapybasic-helix-loop-helixbraincoactivatorglucocorticoidsmineralocorticoid receptor knockouttranscription biologydopaminergic gene polymorphismsaffective temperamentobesityalpha-synucleinSNCAmajor depressionHamilton Scale of Depressionchemokinesneuroinflammationsocial defeatImmune responseT cellssusceptibilityresilienceTreg cellsTh17 cellsbehaviorPPARγMedicineMental health servicesRein Theoedt1280404Fries Gabriel RedtRein TheoothFries Gabriel RothBOOK9910557793503321Molecular Psychiatry3016893UNINA