05319nam 2201261z- 450 991055779060332120231214133606.0(CKB)5400000000045482(oapen)https://directory.doabooks.org/handle/20.500.12854/76962(EXLCZ)99540000000004548220202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStaphylococcal Infections (Host and Pathogenic Factors)Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (226 p.)3-0365-1418-X 3-0365-1417-1 Although 30% of the healthy human population is colonized with various Staphylococcus species, some staphylococcal strains, referred to as opportunistic pathogens, can cause minor to life-threatening diseases. The pathogenicity of these bacteria depends on their virulence factors and the robustness of the regulatory networks expressing these virulence factors. Virulence factors of pathogenic Staphylococcus spp. consist of numerous toxins, enterotoxins (some of which act as superantigens), enzymes, and proteins (cytoplasmic, extracellular, and surface) that are regulated by two-component (TC) and quorum-sensing (QS) regulatory networks. To enter this niche, some other Staphylococcus species, such as Staphylococcus simulans, produce a potent endopeptidase called lysostaphin, which can inhibit the growth of pathogenic S. aureus. Some other Staphylococcus species produce autolysins and cationic peptides to win the intra- and inter-species competition. The outcome of this microbial invasion depends not only on pathogenic factors but also on the host’s internal and external defense mechanisms, including a healthy skin microbiome. A healthy skin microbiome population can prevent colonization by other major pathogens. As normal host microflora, these commensals establish a complex relationship with the host as well as the surrounding microbial communities. This Special Issue of Microorganisms is focused on studies and recent advancements in our understanding of staphylococcal virulence mechanisms that enable Staphylococcus spp. either to successfully establish themselves as a colonizer or to overcome the host’s defense system to cause infection along with our effort to make an anti-staphylococcal vaccine.Staphylococcal Infections Research & information: generalbicsscBiology, life sciencesbicsscbiofilmMRSAsilver ionsilver sulfadiazinewound infectionsStaphylococcus aureusmethicillin resistancehuman infectionCC130biomaterialsmedical devicesHL-60 cellsPMNsendotracheal tubetitaniumimplantable devicesnosocomial diseasesStaphylococcus lugdunensissortase Asurface proteinsLPXTGsmall colony variantsinfluenza virussuper-infectionpro-inflammatory responserural Ghanamolecular epidemiologychronic woundsinvasive diseasesurgery-associated infectionsepsisSA4Ag vaccineconjugated polysaccharideClfAMntCprotectionanimal modelsphase variationStaphylococcus epidermidismicrobiotamultidrug resistancegenome sequencingphylogenetic analysesarthroplasty surgerymethicillin-resistant Staphylococcus aureus (MRSA)community-associated MRSA (CA-MRSA)CA-MRSA strain USA300murine skin infection modeldermatopathologydermonecrosisneutrophilhost antibacterial responsecytokinechemokinephysiologymetabolismcarbon catabolite repressionCcpAHPrcolonizationmouseJSNZaurintricarboxylic acidATAadhesion inhibitormupirocinnosesuperantigenmastitisfood intoxicationregulationsec variantsCM lipidsdaptomycin resistanceresensitizationResearch & information: generalBiology, life sciencesAdhikari Rajan Pedt1297576Adhikari Rajan PothBOOK9910557790603321Staphylococcal Infections (Host and Pathogenic Factors)3024567UNINA