04876nam 2201189z- 450 991055778800332120231214133047.0(CKB)5400000000045508(oapen)https://directory.doabooks.org/handle/20.500.12854/68946(EXLCZ)99540000000004550820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStem Cell Bioprocessing and ManufacturingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (170 p.)3-03943-038-6 3-03943-039-4 The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.Medicinebicsscelectrospinninglive-cell electrospinningtissue engineeringcell seedinghigh voltageviabilityallogeneic cell therapyinduced pluripotent stem cellhuman embryonic stem cellcell aggregateexpansiondifferentiationscalable manufacturingscale upsingle-use bioreactorVertical-WheelU-shaped vesselcomputational fluid dynamicsshear stressturbulent energy dissipation rateshomogeneous hydrodynamic environmenthuman pluripotent stem cellshepatic cell lineageshepatocyte differentiationnon-parenchymal liver cellsliver organoidsdisease modelingdrug screeningolfactory ensheathing cellsspinal cord injuryneural regenerationcell therapiesadipose stem cellsneurotrophic factorsgrowth factorsperipheral nerve injuriesfibrin nerve conduitshydrogelsstem cells deliveryaxonal regenerationSchwann cellsstromal vascular fractionstem celladipose-derived stem cellinfrapatellar fat padkneearthroscopyarthrotomybioreactorhMSCsmicrocarrierbioprocessembryonic stem cellsmesenchymal stromal cellsblood plateletscell culture techniquesprogenitor cellshuman adipose stem cells (hASCs)serum- and xeno-free conditionsUrSuppe stem cell culture mediumautologous therapykinetic growth modelingsegregated and unstructured growth modelmodel predictive controlbio-processcell growthlactateadvanced therapy medicinal productsMedicineCabral Joaquim M. Sedt1324160Lobato da Silva CláudiaedtDiogo Maria MargaridaedtCabral Joaquim M. SothLobato da Silva CláudiaothDiogo Maria MargaridaothBOOK9910557788003321Stem Cell Bioprocessing and Manufacturing3035969UNINA