04913nam 2201213z- 450 991055778800332120210501(CKB)5400000000045508(oapen)https://directory.doabooks.org/handle/20.500.12854/68946(oapen)doab68946(EXLCZ)99540000000004550820202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStem Cell Bioprocessing and ManufacturingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (170 p.)3-03943-038-6 3-03943-039-4 The next healthcare revolution will apply regenerative medicines using human cells and tissues. The aim of the regenerative medicine approach is to create biological therapies or substitutes in vitro for the replacement or restoration of tissue function in vivo lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is an immediate and long-term need for expertise with the necessary skills to face the engineering and life science challenges before the predicted benefits in human healthcare can be realized. Specifically, there is a need for the development of bioprocess technology for the successful transfer of laboratory-based practice of stem cell and tissue culture to the clinic as therapeutics through the application of engineering principles and practices. This Special Issue of Bioengineering on Stem Cell Bioprocessing and Manufacturing addresses the central role in defining the engineering sciences of cell-based therapies, by bringing together contributions from worldwide experts on stem cell biology and engineering, bioreactor design and bioprocess development, scale-up, and manufacturing of stem cell-based therapies.Medicinebicsscadipose stem cellsadipose-derived stem celladvanced therapy medicinal productsallogeneic cell therapyarthroscopyarthrotomyautologous therapyaxonal regenerationbio-processbioprocessbioreactorblood plateletscell aggregatecell culture techniquescell growthcell seedingcell therapiescomputational fluid dynamicsdifferentiationdisease modelingdrug screeningelectrospinningembryonic stem cellsexpansionfibrin nerve conduitsgrowth factorshepatic cell lineageshepatocyte differentiationhigh voltagehMSCshomogeneous hydrodynamic environmenthuman adipose stem cells (hASCs)human embryonic stem cellhuman pluripotent stem cellshydrogelsinduced pluripotent stem cellinfrapatellar fat padkinetic growth modelingkneelactatelive-cell electrospinningliver organoidsmesenchymal stromal cellsmicrocarriermodel predictive controln/aneural regenerationneurotrophic factorsnon-parenchymal liver cellsolfactory ensheathing cellsperipheral nerve injuriesprogenitor cellsscalable manufacturingscale upSchwann cellssegregated and unstructured growth modelserum- and xeno-free conditionsshear stresssingle-use bioreactorspinal cord injurystem cellstem cells deliverystromal vascular fractiontissue engineeringturbulent energy dissipation ratesU-shaped vesselUrSuppe stem cell culture mediumVertical-WheelviabilityMedicineCabral Joaquim M. Sedt1324160Lobato da Silva CláudiaedtDiogo Maria MargaridaedtCabral Joaquim M. SothLobato da Silva CláudiaothDiogo Maria MargaridaothBOOK9910557788003321Stem Cell Bioprocessing and Manufacturing3035969UNINA