04028nam 2200997z- 450 991055778350332120220111(CKB)5400000000045554(oapen)https://directory.doabooks.org/handle/20.500.12854/76427(oapen)doab76427(EXLCZ)99540000000004555420202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCentenarians-A Model to Study the Molecular Basis of Lifespan and HealthspanBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (204 p.)3-0365-0980-1 3-0365-0981-X People around the world are living longer. For the first time in history, most humans will live to be sixty and beyond. By 2050, the world's population aged 60 and over will reach a total of 2 billion, up from 900 million in 2015. Today, 125 million people are 80 years of age or older. By 2050, there will be 434 million people in this age group worldwide. In addition, the pace of aging of the world population is also increasing. However, there is not enough evidence to show that older people have better health than their parents. While rates of severe disability have declined over the past 30 years (but only in high-income countries), there have been no significant changes in mild to moderate disability over the same period of time. Indeed, the increase in the duration of life (lifespan) does not coincide with the increase in the duration of health (healthspan), that is, the period of life free from serious chronic diseases and disabilities. Therefore, the identification of the factors that predispose to a long and healthy life, as discussed in the papers of this book, is of enormous interest for translational medicine.Biology, life sciencesbicsscResearch & information: generalbicsscageingagingaging-related diseaseallergyalternative therapyapoptosisC. eleganscellular senescencecentenarianscomposition of royal jellydefective mitosisDi (2-Ethylhexyl) pthalatedietary interventionsDNA methylationDNA-damage responseelderlyepigenetic clocksexosomesfood allergyfunctional enrichment analysisglutathioneguthealthspanhealthy agingHericium erinaceushypersensitivityIGF-1immunosenescenceinflammationingenuity pathway analysislamin B1lifespanlongevitymeniere's diseasemiRNA-mRNA networksmitochondrial respiratory complexesn/anematodeneurodegenerative diseasesolive oiloxidative stressParkinson's diseasepathogen protectionpolyphenolsprobiotic bacteriaredoxomicsroyal jellyserumtelomere lengthvitagenesβ-DystroglycanBiology, life sciencesResearch & information: generalPuca Annibaleedt1328819Caruso CalogeroedtPuca AnnibaleothCaruso CalogeroothBOOK9910557783503321Centenarians-A Model to Study the Molecular Basis of Lifespan and Healthspan3645513UNINA