04519nam 2201069z- 450 991055778160332120220111(CKB)5400000000045573(oapen)https://directory.doabooks.org/handle/20.500.12854/76798(oapen)doab76798(EXLCZ)99540000000004557320202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMultimodal Therapy of Upper Gastrointestinal MalignanciesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (272 p.)3-0365-0920-8 3-0365-0921-6 Recent decades have seen remarkable advances in the treatment of upper gastrointestinal malignancies, i.e., adenocarcinoma and squamous cell carcinoma as well as gastrointestinal stromal and other rare tumors of the esophagus and stomach. While, historically, surgical resection has been the sole treatment for these tumors, multimodal therapies have meanwhile proven their efficacy. At present, pre- and postoperative chemotherapy and radiotherapy, targeted drug therapy, and stage-specific surgical approaches are all indispensable cornerstones of an individualized treatment for upper gastrointestinal malignancies. With such multimodal treatment, better outcomes comprising improved quality of life and prolonged survival have been achieved for patients. However, for many tumor entities and stages, the ideal combination and sequence of treatments is still being evaluated in clinical trials. Moreover, the value of novel approaches such as immunotherapy or robotic surgery remains a matter of research. In this Special Issue of Cancers, up-to-date original research, short communications, and comprehensive review articles on all modalities playing a role in the treatment of upper gastrointestinal malignancies have been published.Public health and preventive medicinebicsscadjuvant therapyBarrett's esophaguscancer dormancychemo-radiotherapyclinical pathwayscomplicationsconversion surgerydefinitive chemoradiotherapyearly adenocarcinoma of esophagusendoscopic mucosal resectionendoscopic submucosal dissectionesophageal anastomosisesophageal canceresophageal squamous cell carcinomaesophagectomyfailure to rescuegastrectomygastric cancergastric surgerygastric/gastroesophageal cancergastro-esophageal reflux diseasegastrointestinal stromal tumorgastrointestinal tractgenetic diagnosisgeneticsGISTimatinibimmunotherapyinduction chemotherapyLauren histotypelymph node ratioMALT lymphomaminimally invasive surgerymortalitymucosal resectionmultidisciplinarymultimodal treatmentn/aneoadjuvant chemoradiotherapyneoadjuvant chemotherapyneoadjuvant therapyneoadjuvant treatmentneuroendocrine tumornuclear receptor NR2F1nutritional statusoncological gastrectomyorgan preservationoutcomeoutcomesoverall survivalperioperative chemotherapyquality of careradiosensitivityrelapse-free survivalsarcopeniaskeletal muscle indexsquamous cell esophageal cancerstandardizationstomachsubmucosal dissectionsurvivalPublic health and preventive medicineRonellenfitsch Ulrichedt1309877Ronellenfitsch UlrichothBOOK9910557781603321Multimodal Therapy of Upper Gastrointestinal Malignancies3029691UNINA