05857nam 2201441z- 450 991055776110332120231214132838.0(CKB)5400000000045751(oapen)https://directory.doabooks.org/handle/20.500.12854/76512(EXLCZ)99540000000004575120202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.0Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (286 p.)3-0365-0256-4 3-0365-0257-2 This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.Cytochromes P450Research & information: generalbicsscAntibioticsBacillusbiosynthetic gene clusterscomparative analysiscytochrome P450 monooxygenaseMycobacteriumP450 diversity percentageP450 profilingsecondary metabolitesNADPH-cytochrome P450 reductase (CPR)microsomal cytochrome P450 (CYP)Cytochrome b5 (CYB5)protein dynamicselectron-transfer (ET)protein–protein interactioncytochromes P450CYP3A4active site access channelscavities boundariesminimal cost pathsCYP139A1genome data mininghost metabolismMycobacterium tuberculosispolyketidestuberculosiscryptococcuscryptococcus neoformansCYP51fungal pathogensgenome data-mininghuman pathogensCYP diversity analysistremellomycetestrichosporonmechanism-based inhibitorcrystal structureCYP4 genesgenetic polymorphisms20-HETEfatty acidarachidonic acidSNPsmolecular functionalitymetabolismlamellar ichthyosisBietti’s crystalline dystrophycytochrome P450isoformmembrane proteinprotein-membrane interactionsenzyme substrate specificitymutagenesismolecular dynamics simulationSogatella furciferasulfoxaflortranscriptomeRNA interferenceCYP2C8polymorphismsreactive oxygen speciespaclitaxelcytochrome P450 reductaseelectron transferextracellular vesiclesexosomesextrahepatic tissuesplasmacirculatory CYPsCYP450drug metabolismprecision Cardio-Oncologyprecision medicinesystems medicinecytochromes P450 monooxygenasesCyanobacteriagene-cluster diversity percentagemathematical formulaphylogenetic analysisStreptomycescytochrome P450 monooxygenasesterpenesP450 bloomingnon-ribosomal peptidescytochrome P450 monooxygenenasesCYP128A1Mycobacterium tuberculosis H37Rvmolecular dynamic simulationsazole drugsmenaquinoneResearch & information: generalDansette Patrick Medt1319364Werck DanièleedtDansette Patrick MothWerck DanièleothBOOK9910557761103321Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity 2.03033829UNINA