04448nam 2201165z- 450 991055776020332120210501(CKB)5400000000045760(oapen)https://directory.doabooks.org/handle/20.500.12854/68274(oapen)doab68274(EXLCZ)99540000000004576020202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierOligodendrocyte Physiology and Pathology FunctionBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (330 p.)3-03943-689-9 3-03943-690-2 The adult vertebrate central nervous system mainly consists of neurons, astrocytes, microglia cells, and oligodendrocytes. Oligodendrocytes, the myelin-forming cells of the CNS, are subjected to cell stress and subsequent death in a number of metabolic or inflammatory disorders, among which multiple sclerosis (MS) is included. This disease is associated with the development of large demyelinated plaques, oligodendrocyte destruction, and axonal degeneration, paralleled by the activation of astrocytes and microglia as well as the recruitment of peripheral immune cells to the site of tissue injury. Of note, viable oligodendrocytes and an intact myelin sheath are indispensable for neuronal health. For example, it has been shown that oligodendrocytes provide nutritional support to neurons, fast axonal transport depends on proper oligodendrocyte function, and mice deficient in mature myelin proteins eventually display severe neurodegeneration. This Special Issue contains a collection of highly relevant primary research articles as well as review articles focusing on the development, physiology, and pathology of the oligodendrocyte-axon-myelin unit.Medicine and NursingbicsscNeurosciencesbicssc18F-FDGageastrocyteastrocytesatrophycaffeineCNScognitionconditional knockoutcorpus callosum (CC)cre-recombinasecross-talkcuprizonecuprizone modeldemyelinationdesign-based stereologyDigiGait™down syndromedrug screeningEGFR inhibitorenergy drinksepigeneticsexperimental autoimmune encephalomyelitisexperimental autoimmune encephalomyelitis (EAE)gait analysisglial cells.glial fateglial progenitor cellsimmunohistochemistryinterneuronlaquinimodliquid chromatography-mass spectrometrymacromolecular proton fractionmagnetic resonance imagingmicrofibersmicrogliaMPFmultiple sclerosismurine acute brain slicesmyelinmyelinationn/ananofibersneurodegenerationneuronNsun5oligodendrocyteoligodendrocyte (OL)oligodendrocyte precursorsoligodendrocyte progenitor cellsoligodendrocytesOPCplasma membrane proteinspluripotent stem cellsrat cerebellumremyelinationreproducibilityschizophreniascreeningsmoothened agonisttamoxifentaurinetransient receptor potential ankyrin 1treatmentwhite matterwhite matter diseaseWilliams-Beuren syndrome (WBS)Medicine and NursingNeurosciencesKipp Markusedt1324155Kipp MarkusothBOOK9910557760203321Oligodendrocyte Physiology and Pathology Function3035962UNINA