04011nam 2201021z- 450 991055774980332120240318195924.0(CKB)5400000000045844(oapen)https://directory.doabooks.org/handle/20.500.12854/68279(EXLCZ)99540000000004584420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAsthmaCurrent Perspectives on Phenotypes, Endotypes, and Treatable TraitsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (280 p.)3-03943-859-X 3-03943-860-3 Asthma is a common complex and heterogeneous respiratory disease with an increasing prevalence in developed countries. Asthma is a disease consisting of different phenotypes that are driven by different mechanistic pathways (endotypes). The recognition of these phenotypes and endotypes is central to asthma management entailing prognostic and therapeutic implications. It is acknowledged that despite optimal treatment, many patients are poorly controlled, highlighting the need for phenotype-guided treatments. In this context, the emergence of novel therapies (monoclonal antibody therapy, bronchial thermoplasty) is paving the way for personalized asthma therapy. A better understanding of disease pathogenesis may enable the identification of biomarkers, mediators, novel therapeutic targets, and treatable traits. Further molecular phenotyping or endotyping of asthma will be necessary to tailor new therapeutic strategies. The present Special Issue on Asthma aims to provide the current knowledge on phenotypes and endotypes in appreciating and managing the heterogeneous condition that is asthma.AsthmaMedicinebicsscasthmalactic acidosishyperchloremic acidosishypocapniahypercapniawheezingbronchial biopsiessymptom persistenceclinical remissioneosinophiladhesionviabilityproliferationairway smooth muscle cellpulmonary fibroblastphenotypeacute severe asthma exacerbationnear fatal asthmasevere asthmainflammationinterleukin-5 (IL-5)anti-IL-5interleukin-4airway remodelingmatrix metalloproteinases-9tissue inhibitor of metalloproteinase-1alveolar macrophageslung functionbronchodilationresistanceobstructionreproduciblespirometryobstructive sleep apneabronchial asthmaalternative overlap syndromeexacerbationreactive oxygen speciesPBMCmitochondrial functioninnate immunityimmune regulationNLRP3IL-1βallergic airway inflammationmicrobiomepathogenesisimmune responsesPreDictapreschoolFeNOasthma-specific quality of lifechronic rhinitisdisease-specific quality of lifehealth-related quality of Life (HRQLQ)childrenlongitudinal studyMedicineRovina Nikolettaedt1280957Rovina NikolettaothBOOK9910557749803321Asthma3017748UNINA