05804nam 2201621z- 450 991055774660332120231214133643.0(CKB)5400000000045876(oapen)https://directory.doabooks.org/handle/20.500.12854/69041(EXLCZ)99540000000004587620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicrobial Virulence FactorsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (400 p.)3-03936-946-6 3-03936-947-4 Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.Research & information: generalbicsscBiology, life sciencesbicsscAeromonas hydrophilaLysR-familyΔlahSglobal regulatorvirulenceSclerotinia sclerotiorumSsNsd1compound appressoriumtwo-dimensional electrophoresisproteomics analysisdifferential expression proteinscystic fibrosisPseudomonas aeruginosaBurkholderia cepacia complexsmall noncoding regulatory RNAspathogenicityusgtruASalmonella enterica serovar Typhimuriumoxidative stressintracellular survivalpathogenomicscoagulase-negative staphylococcivirulence factorswhole genome sequencingautotransportercovalent labelingbacterial surface proteinSpyCatchertopology mappingvirulence factorCandidahost-pathogen interactionbiofilm formationmorphologyimmune evasionTrueperella pyogenespyolysininfectionimmune responseActinomycetalesBordetella pertussisHfqomics analysisT3SSserum resistancesolute-binding proteinsphytoplasmaeffector proteinappleapple proliferationbacteriablood–brain barrierblood–cerebrospinal fluid barriermeningitisouter membrane vesicles (OMVs)Candida albicansantimicrobial peptidescomplementinterspecies interactionsinter-kingdom protectionfungicidal activityfluconazolehyphaeantimicrobial peptideEDTAprimary ciliary dyskinesiaanti-virulencesputumchronic infectionEnterobacteralesKlebsiellaEnterobacterCitrobacterantibiotic resistancebiofilmSPATEsUTIscytotoxicityserine proteases5637 bladder cellsmucingelatinactinprotease LonDickeya solaniplant pathogenmotilitytype III secretion systemresistance to stresslon expressionpectinolytic enzymesgene expressionmanipulationinflammationpersistencereplicative nicheactin proteolysismetalloproteinasesprotease ECP 32grimelysinprotealysinbacterial invasionmicrobial virulence factorsbacterial pathogensfungal pathogensResearch & information: generalBiology, life sciencesLeitão Jorge Hedt1326281Leitão Jorge HothBOOK9910557746603321Microbial Virulence Factors3037260UNINA