05821nam 2201633z- 450 991055774660332120210501(CKB)5400000000045876(oapen)https://directory.doabooks.org/handle/20.500.12854/69041(oapen)doab69041(EXLCZ)99540000000004587620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMicrobial Virulence FactorsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (400 p.)3-03936-946-6 3-03936-947-4 Microbial virulence factors encompass a wide range of molecules produced by pathogenic microorganisms, enhancing their ability to evade their host defenses and cause disease. This broad definition comprises secreted products such as toxins, enzymes, exopolysaccharides, as well as cell surface structures such as capsules, lipopolysaccharides, glyco- and lipoproteins. Intracellular changes in metabolic regulatory networks, governed by protein sensors/regulators and non-coding regulatory RNAs, are also known to contribute to virulence. Furthermore, some secreted microbial products have the ability to enter the host cell and manipulate their machinery, contributing to the success of the infection. The knowledge, at the molecular level, of the biology of microbial pathogens and their virulence factors is central in the development of novel therapeutic molecules and strategies to combat microbial infections. The present collection comprises state of the art research and review papers on virulence factors and mechanisms of a wide range of bacterial and fungal pathogens for humans, animals, and plants, thus reflecting the impact of microorganisms in health and economic human activities, and the importance of the topic.Biology, life sciencesbicsscResearch and information: generalbicssc5637 bladder cellsactinactin proteolysisActinomycetalesAeromonas hydrophilaanti-virulenceantibiotic resistanceantimicrobial peptideantimicrobial peptidesappleapple proliferationautotransporterbacteriabacterial invasionbacterial pathogensbacterial surface proteinbiofilmbiofilm formationblood-brain barrierblood-cerebrospinal fluid barrierBordetella pertussisBurkholderia cepacia complexCandidaCandida albicanschronic infectionCitrobactercoagulase-negative staphylococcicomplementcompound appressoriumcovalent labelingcystic fibrosiscytotoxicityDickeya solanidifferential expression proteinsEDTAeffector proteinEnterobacterEnterobacteralesfluconazolefungal pathogensfungicidal activitygelatingene expressionglobal regulatorgrimelysinHfqhost-pathogen interactionhyphaeimmune evasionimmune responseinfectioninflammationinter-kingdom protectioninterspecies interactionsintracellular survivalKlebsiellalon expressionLysR-familymanipulationmeningitismetalloproteinasesmicrobial virulence factorsmorphologymotilitymucinomics analysisouter membrane vesicles (OMVs)oxidative stresspathogenicitypathogenomicspectinolytic enzymespersistencephytoplasmaplant pathogenprimary ciliary dyskinesiaprotealysinprotease ECP 32protease Lonproteomics analysisPseudomonas aeruginosapyolysinreplicative nicheresistance to stressSalmonella enterica serovar TyphimuriumSclerotinia sclerotiorumserine proteasesserum resistancesmall noncoding regulatory RNAssolute-binding proteinsSPATEssputumSpyCatcherSsNsd1T3SStopology mappingtruATrueperella pyogenestwo-dimensional electrophoresistype III secretion systemusgUTIsvirulencevirulence factorvirulence factorswhole genome sequencingΔlahSBiology, life sciencesResearch and information: generalLeitão Jorge Hedt1326281Leitão Jorge HothBOOK9910557746603321Microbial Virulence Factors3037260UNINA