04181nam 2201129z- 450 991055774160332120210501(CKB)5400000000045926(oapen)https://directory.doabooks.org/handle/20.500.12854/68974(oapen)doab68974(EXLCZ)99540000000004592620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRole of Genomics in the Management of HypertensionBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (200 p.)3-03936-627-0 3-03936-628-9 Arterial hypertension affects about 1 billion people worldwide and it is the strongest modifiable risk factor for cardiovascular disease and related disability. Since the initial discovery of rare monogenic disorders with large effects, the role of genomics has evolved into large genome-wide association studies detecting common variants with a modest effect size. Similarly, pharmacogenomics has emerged as a new tool for understanding variability in drug response, to maximize efficacy and reduce toxicity. This book presents the most recent advances in the field of genetics and genomics of arterial hypertension and their potential impact on clinical management. The book is a useful tool for clinicians but also to the research community and those who want to be updated in the field.Biology, life sciencesbicsscResearch & information: generalbicsscadducinAfrican Americanaldosteronealdosterone-producing adenomaARMC5atrial natriuretic peptideblood pressureburden testCACNA1Dcardiac hypertrophycardio-tonic steroidscardiovascular diseasescervical artery dissectionCRY1CRY2DNA methylationendocrine hypertensionendogenous ouabainendothelial cellsendothelial dysfunctionepigeneticsessential hypertensionexome microarrayfibromuscular dysplasiagenetic associationgeneticsgenetics of left ventricular hypertrophygenome-wide association studiesGRK4heart failurehistone modificationsHSD3B1HSD3B2hypertensionhypokalemiaKruppel-like factor 15left ventricular hypertrophyLiddle syndromelow renin hypertensionlow-reninmicro RNAmineralocorticoid receptormonogenic hypertensionnext-generation sequencingnon atherosclerotic vascular stenosisnon-coding RNAPHACTR1platelet aggregationprimary aldosteronismrare variantsrare-variants association testingrenal damagereninSCNN1ASCNN1BSCNN1Gsequence kernel association testsmooth muscle cells contractionspontaneous coronary arteries dissectionT2238C varianttranscriptome profiingvascular smooth muscle cellsBiology, life sciencesResearch & information: generalMulatero Paoloedt1329482Monticone SilviaedtMulatero PaoloothMonticone SilviaothBOOK9910557741603321Role of Genomics in the Management of Hypertension3039499UNINA