03707nam 2201069z- 450 991055773570332120220111(CKB)5400000000045986(oapen)https://directory.doabooks.org/handle/20.500.12854/76486(oapen)doab76486(EXLCZ)99540000000004598620202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierInsulin-Like Growth Factors in Development, Cancers and AgingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (196 p.)3-0365-0770-1 3-0365-0771-X This Special Issue of Cells on "Insulin-Like Growth Factors in Development, Cancers and Aging" provides a collection of modern articles dealing with the role of insulin-like growth factors (IGF1) in cancer biology, aging and development. Featured articles explore basic and clinical aspects of the IGF1 system, including post-genomic analyses as well as novel approaches to target the IGF1 receptor (IGF1R) in oncology. The present Special Issue highlights some of the most important topics in the broad area of IGF research, including the role of IGF1 in aging and longevity, attempts to target the IGF1 axis in oncology, the role of IGF-binding proteins, structural aspects of IGF-II, etc. We trust that this assembly of articles will be of great help to students, basic researchers and practitioners.Biology, life sciencesbicsscResearch & information: generalbicsscage-related diseaseagingagonistsanti-metastaticanti-tumoratrophyautophagycachexiacognitive impairmentdiabetesfunctional RTK/GPCR hybridG-proteinsglucose regulated protein (GRP) 94GPCRsgrowth hormonehealth-spanhybridshypertrophyIGF systemIGF-1IGF-1RIGF-IIGF-I receptorIGF-IIIGF-IRIGF-TrapIGFBPIGFBP-1IGFBP-3IGFBP-3Rinsulininsulin receptorinsulin-like growth factorinsulin-like growth factor-1IR-AIRslongevitylongitudinal studymAb therapymitochondriamouse modelsMSCsmuscle regenerationmyogenesisn/anuclear translocationobligate chaperoneolder adultsoxidative stressphosphorylationreceptor activationsenescencesignalingskeletal musclestructural studiestargeted therapeuticsTMEM219tyrosine kinase receptorβ-arrestinsBiology, life sciencesResearch & information: generalWerner Haimedt1287877Werner HaimothBOOK9910557735703321Insulin-Like Growth Factors in Development, Cancers and Aging3020512UNINA