02311nam 2200457z- 450 991055771760332120231214133057.0(CKB)5400000000046149(oapen)https://directory.doabooks.org/handle/20.500.12854/73719(EXLCZ)99540000000004614920202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierShankopathies: Shank Protein Deficiency-Induced Synaptic DiseasesFrontiers Media SA20201 electronic resource (231 p.)2-88963-567-8 Shank (also known as ProSAP) is a family of postsynaptic scaffolding proteins that are thought to be involved in the regulation of excitatory synapse development, function, and plasticity. The Shank family contains three known members (Shank1, Shank2, and Shank3). These proteins are equipped with various domains for protein-protein interactions known to mediate direct and indirect interactions with many other synaptic proteins, including glutamate receptors, other synaptic scaffolding proteins, and signaling molecules. Importantly, Shank has been implicated in diverse neuropsychiatric disorders, including autism spectrum disorders, schizophrenia, and Phelan-McDermid syndrome, a form of developmental delay and intellectual disability. The mechanisms underlying these abnormalities, collectively termed "Shankopathies," are being actively investigated, although overall progress has been slow for many reasons.ShankopathiesScience: general issuesbicsscNeurosciencesbicsscShankShankopathiesneuropsychiatric disordersmodulating factorsbrain regionsScience: general issuesNeurosciencesEy Elodieedt1330027Bourgeron ThomasedtBoeckers Tobias MedtKim EunjoonedtHan KihoonedtEy ElodieothBOOK9910557717603321Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases3039702UNINA