04419nam 2201345z- 450 991055771720332120210501(CKB)5400000000046153(oapen)https://directory.doabooks.org/handle/20.500.12854/68994(oapen)doab68994(EXLCZ)99540000000004615320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMatrix MetalloproteinaseBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (262 p.)3-03936-648-3 3-03936-649-1 Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in biology. This editorial mini-review summarizes the Special Issue, which includes four review articles and 10 original articles that highlight the versatile roles of MMPs, ADAMs, and ADAMTSs, in normal physiology as well as in neoplastic and destructive processes in tissue. In addition, we briefly discuss the unambiguous involvement of MMPs in wound healing.Biology, life sciencesbicsscResearch & information: generalbicssca disintegrin and metalloproteinaseADAMADAMTSadultaggrecanaggrecanaseAgkistrodon venomallodyniaanticoagulantsantithromboticapoptosisarthritisblood samplingcancercartilagecaspase-3CD147central nervous systemchemokinecytokinecytokinesdiseasesdorsal root ganglionectodomain sheddingEMMPRINextracellular matrixextracellular matrix breakdownfibrinogengastric cancerglycosaminoglycansglycosylationhemagglutinin-Bhigh-molecular-weight heparinHIV-TB-associated IRISIL-11IL-16IL-6IL-8inflammationinhibitorinterferoninterleukininterstitial collagensinvasionlungmatrix metalloproteinasematrix metalloproteinasesmatrix metalloproteinases (MMPs)matrix-metalloproteinasemeprinmetabolomicsmetalloproteasesmetalloproteinasemetastatic disseminationMMPMMP-2MMP-9MMPsmonocytesMT4-MMPneuropathicpainpediatricperitoneal mesothelial cellphagocytosisphosphorylationproteaseproteinasesproteomicsPTMssICAM-1signalingspinal nerve ligationT cellsTNF-αtrans-signalingtranswell co-culturestuberculosistuberculous meningitiswound healingBiology, life sciencesResearch & information: generalÅgren Magnus Sedt1309861Keller UlrichedtÅgren Magnus SothKeller UlrichothBOOK9910557717203321Matrix Metalloproteinase3029672UNINA