05551nam 2201489z- 450 991055770560332120231214133415.0(CKB)5400000000046223(oapen)https://directory.doabooks.org/handle/20.500.12854/68639(EXLCZ)99540000000004622320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNatural Products and NeuroprotectionBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (338 p.)3-03936-216-X 3-03936-217-8 Neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are the most common pathologies of the central nervous system currently without a cure. They share common molecular and cellular characteristics, including protein misfolding, mitochondrial dysfunction, glutamate toxicity, dysregulation of calcium homeostasis, oxidative stress, inflammation, and ageing, which contribute to neuronal death. Efforts to treat these diseases are often limited by their multifactorial etiology. Natural products, thanks to their multitarget activities, are considered promising alternatives for the treatment of neurodegeneration. This book deals with two different forms of natural products: extracts and isolated compounds. The study of the bioactivity of the extracts is extremely important as many studies have demonstrated the synergistic effect of the combination of different natural products. On the other hand, the investigation of the activity of specifically isolated natural products can be also important to understand their cellular and molecular mechanisms and to define the specific bioactive components in extracts or foods. This book can be considered an important contribution to knowledge of the neuroprotective effect of natural products and presents a great deal of information, related to both the benefits but also the limitations of their use in counteracting neurodegeneration.Research & information: generalbicsscBiology, life sciencesbicsscVitamin DMultiple Sclerosissymptomneurodegenerationoxidative injuryParkinson's diseaseterpenes, rotenonethymolAlzheimer's diseaseCentella asiaticahippocampusprotein poshophatase 2glycogen synthase kinase 3B-cell lymphoma 2neuroprotectionnutraceuticalsbioavailabilitystress responseneurodegenerative diseasebioactive compoundnatural extractβ-amyloid peptidetau proteinclinical trialhuman studiesanimal studiesin vitro studiescurcuminfree radicalsheme oxygenasesafety profiletype 2 diabetesinflammationvascular damagelearningmemorynatural compoundoxidative stresscognitive dysfunctioncell deathsynapse lossprotein aggregationneuroinflammationalgaeseaweedsneurodegenerative diseasesauraptenedopamine neuronantioxidantmitochondriaChionanthus retususflavonoidflowerHO-1NOLippia citriodoraVEEVsrelaxationdepressioncyclic AMPcalciumblood-brain barriercatechincognitionepigallocatechin gallategreen teamicrobiota5-(3,5-dihydroxyphenyl)-γ-valerolactoneascaroside pheromoneC. elegansdauerneuronal signalingsexual behaviorsurvival signalsproteostasischaperonesautophagyubiquitin-proteasomeunfolded protein responsenatural compoundsnatural productsethicspatients' autonomybeneficencenonmaleficencemedical liabilityParkinson's disease (PD)mitochondrial dysfunctiondynamicshormesisubiquitin‒proteasome system (UPS)mitophagyResearch & information: generalBiology, life sciencesAngeloni Cristinaedt1299450Vauzour DavidedtAngeloni CristinaothVauzour DavidothBOOK9910557705603321Natural Products and Neuroprotection3025178UNINA