03800nam 2201033z- 450 991055770200332120231214133404.0(CKB)5400000000046260(oapen)https://directory.doabooks.org/handle/20.500.12854/76473(EXLCZ)99540000000004626020202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierP38 Signaling PathwayBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (194 p.)3-0365-0858-9 3-0365-0859-7 p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.Research & information: generalbicsscarginine methylationerythroid differentiationMKK3phosphorylation, PRMT1p38 MAPKcocaineconditioned place preferencerewardstressanxietydepressionnucleus accumbenssocial interactionk opioid receptorsp38αRab5endosomeAlzheimer'sLewy Bodiesamyloid-βtauα-synucleinp38-MAPK α inhibitorAlzheimer's diseasesynaptic plasticityneuroinflammationβ-amyloidTauKv4.2seizuretemporal lobe epilepsyhippocampusneuronal firing and excitabilityp38MAPKnuclear translocationβ-like importinsinflammationcancerskeletal muscleenergy metabolismsignal transductionexercisetype 2 diabetesp38 mitogen-activated protein kinasebleomycin-induced pulmonary fibrosisidiopathic pulmonary fibrosisRNA sequencingalveolar epithelial type II cellsMAPKp38physiologymetabolismsignalinghypoxiaarrhythmiaMAPK11p38βResearch & information: generalCuenda Anaedt1327925Sanz Ezquerro Juan JoséedtCuenda AnaothSanz Ezquerro Juan JoséothBOOK9910557702003321P38 Signaling Pathway3038283UNINA