03841nam 2201057z- 450 991055770200332120220111(CKB)5400000000046260(oapen)https://directory.doabooks.org/handle/20.500.12854/76473(oapen)doab76473(EXLCZ)99540000000004626020202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierP38 Signaling PathwayBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (194 p.)3-0365-0858-9 3-0365-0859-7 p38 Mitogen activated protein kinases (p38MAPK) are a group of evolutionary conserved protein kinases which are central for cell adaptation to environmental changes as well as for immune response, inflammation, tissue regeneration and tumour formation. The interest in this group of protein kinases has grown continually since their discovery. Recent studies using new genetic and pharmacological tools are providing helpful information on the function of these stress-activated protein kinases and show that they have an acute impact on the development of prevalent diseases related to inflammation, diabetes, neurodegeneration, and cancer. In this Special Issue we present novel advances and review the knowledge on the identification of p38MAPK substrates, functions, and regulation; mechanisms underlying the role of p38MAPK in malignant transformation and other pathologies; and therapeutic opportunities associated with regulation of p38MAPK activity.Research and information: generalbicsscalveolar epithelial type II cellsAlzheimer'sAlzheimer's diseaseamyloid-βanxietyarginine methylationarrhythmiableomycin-induced pulmonary fibrosiscancercocaineconditioned place preferencedepressionendosomeenergy metabolismerythroid differentiationexercisehippocampushypoxiaidiopathic pulmonary fibrosisinflammationk opioid receptorsKv4.2Lewy BodiesMAPKMAPK11metabolismMKK3n/aneuroinflammationneuronal firing and excitabilitynuclear translocationnucleus accumbensp38p38 MAPKp38 mitogen-activated protein kinasep38-MAPK α inhibitorp38MAPKp38αp38βphosphorylation, PRMT1physiologyRab5rewardRNA sequencingseizuresignal transductionsignalingskeletal musclesocial interactionstresssynaptic plasticitytauTautemporal lobe epilepsytype 2 diabetesα-synucleinβ-amyloidβ-like importinsResearch and information: generalCuenda Anaedt1327925Sanz Ezquerro Juan JoséedtCuenda AnaothSanz Ezquerro Juan JoséothBOOK9910557702003321P38 Signaling Pathway3038283UNINA