05302nam 2201369z- 450 991055770180332120231214133407.0(CKB)5400000000046262(oapen)https://directory.doabooks.org/handle/20.500.12854/69152(EXLCZ)99540000000004626220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStem Cell Research on CardiologyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (356 p.)3-03943-192-7 3-03943-193-5 Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.Research & information: generalbicsscBiology, life sciencesbicsscFabry diseasehuman embryonic stem cellsCRISPR/Cas9 genomic editingMass spectrometry proteomic analysishypertrophic cardiomyopathydisease modelphysical exercisecardiac cellular regenerationmicroRNA (miR)Akt signalingcardiomyocyte proliferationcardiac hypertrophycardioprotectionmyocarditisinflammationleukocytescardiomyocytesmulti-electrode-arraymicro-electrode-arrayMEAdrug/toxicity screeningfield potentialarrhythmiaelectrocardiographycardiac regenerationstem cellsiPSCPSCESCcardiovascular diseaseregenerationcardiac progenitor cellsinduced pluripotent stem cellstransdifferentiationdirect reprogramminggenetic engineeringcardiac tissue engineeringbiomaterials18F-FDG PETcardiac induced cellscardiac functionnon-invasive imaginghuman pluripotent stem cellventricularmaturationbone marrow stem cellsangiogenesismyocardial infarctionhuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)iPS cellsbig conductance calcium activated potassium channel (BK)Maxi-Kslo1KCa1.1iberiotoxinlong QT syndromemesenchymal stromal cells (MSC)mRNAmiRNAcardiac reprogrammingcardiac differentiationcardiovascular diseasesadult stem cellsmyocardial infraction3D printing3D modelbioprintingcardiovascular medicineheartmyocardiumheart valvesvascular graftendothelializationtissue engineeringdecorinfibronectinelectrospinningendothelial progenitor cellsbioreactorbiostable polyurethaneMicroRNAMir-133coronary heart diseasebiomarkermeta-analysisResearch & information: generalBiology, life sciencesDavid Robertedt395764David RobertothBOOK9910557701803321Stem Cell Research on Cardiology3039488UNINA