05323nam 2201381z- 450 991055770180332120210501(CKB)5400000000046262(oapen)https://directory.doabooks.org/handle/20.500.12854/69152(oapen)doab69152(EXLCZ)99540000000004626220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierStem Cell Research on CardiologyBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (356 p.)3-03943-192-7 3-03943-193-5 Even today, cardiovascular diseases are the main cause of death worldwide, and therapeutic approaches are very restricted. Due to the limited regenerative capabilities of terminally differentiated cardiomyocytes post injury, new strategies to treat cardiac patients are urgently needed. Post myocardial injury, resident fibroblasts begin to generate the extracellular matrix, resulting in fibrosis, and finally, cardiac failure. Recently, preclinical investigations and clinical trials raised hope in stem cell-based approaches, to be an effective therapy option for these diseases. So far, several types of stem cells have been identified to be promising candidates to be applied for treatment: cardiac progenitor cells, bone marrow derived stem cells, embryonic and induced pluripotent stem cells, as well as their descendants. Furthermore, the innovative techniques of direct cardiac reprogramming of cells offered promising options for cardiovascular research, in vitro and in vivo. Hereby, the investigation of underlying and associated mechanisms triggering the therapeutic effects of stem cell application is of particular importance to improve approaches for heart patients. This Special Issue of Cells provides the latest update in the rapidly developing field of regenerative medicine in cardiology.Biology, life sciencesbicsscResearch and information: generalbicssc18F-FDG PET3D model3D printingadult stem cellsAkt signalingangiogenesisarrhythmiabig conductance calcium activated potassium channel (BK)biomarkerbiomaterialsbioprintingbioreactorbiostable polyurethanebone marrow stem cellscardiac cellular regenerationcardiac differentiationcardiac functioncardiac hypertrophycardiac induced cellscardiac progenitor cellscardiac regenerationcardiac reprogrammingcardiac tissue engineeringcardiomyocyte proliferationcardiomyocytescardioprotectioncardiovascular diseasecardiovascular diseasescardiovascular medicinecoronary heart diseaseCRISPR/Cas9 genomic editingdecorindirect reprogrammingdisease modeldrug/toxicity screeningelectrocardiographyelectrospinningendothelial progenitor cellsendothelializationESCFabry diseasefibronectinfield potentialgenetic engineeringheartheart valveshuman embryonic stem cellshuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)human pluripotent stem cellhypertrophic cardiomyopathyiberiotoxininduced pluripotent stem cellsinflammationiPS cellsiPSCKCa1.1leukocyteslong QT syndromeMass spectrometry proteomic analysismaturationMaxi-KMEAmesenchymal stromal cells (MSC)meta-analysismicro-electrode-arrayMicroRNAmicroRNA (miR)Mir-133miRNAmRNAmulti-electrode-arraymyocardial infarctionmyocardial infractionmyocarditismyocardiumnon-invasive imagingphysical exercisePSCregenerationslo1stem cellstissue engineeringtransdifferentiationvascular graftventricularBiology, life sciencesResearch and information: generalDavid Robertedt395764David RobertothBOOK9910557701803321Stem Cell Research on Cardiology3039488UNINA