04681nam 2201453z- 450 991055764810332120210501(CKB)5400000000044972(oapen)https://directory.doabooks.org/handle/20.500.12854/69291(oapen)doab69291(EXLCZ)99540000000004497220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierKilling CancerDiscovery and Selection of New Target MoleculesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (302 p.)3-03943-440-3 3-03943-441-1 Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled "Killing Cancer: Discovery and Selection of New Target Molecules". These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.Killing Cancer Biology, life sciencesbicsscResearch & information: generalbicssc3D growthABCG2AF1QanoikisATP-binding cassette transporterATP6V0a3ATR pathwayautophagyBRCA1BRCA2breast cancer resistance protein (BCRP)breast cancer stem cellsC2 domaincancercancer metabolismcancer therapyCD domainchondroitin sulfatecolorectal cancerdexamethasonedisulfiramDNA damagedrug efflux pumpsdysferlinEMTepithelial-mesenchymal transitionERK1ERK2esophageal cancerferlinglucocorticoidsIL-8immunotherapyinflammationinvasionkinase inhibitorslysosomelysosome-mediated invasionmammosphereMAPK kinasematrix degradationmetabolismmicrogravitymicrosatellite instabilitymigrationMLLT11mTOR in immunotherapymTOR inhibitorsmTOR signalingmTORC1mTORC2multidrug resistance in cancermyoferlinMZF1n/aNF-κBNPL4nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB)nutrient metabolismoncofetal chondroitin sulfateotoferlinPAK4PDACpediatric cancerpH-regulationphosphorylationplasma membraneprognosisproliferationpyrazolo-pyrimidine derivativerapalogsreplication stressRolledSCH772984SCO-201sevenmakersolid tumorsspace environmentSTATsulconazoleSUMOylationtargettargeted cancer therapyTCIRG1thyroid cancertranscription factorVAR2VRT-11EWNTzinc fingerBiology, life sciencesResearch & information: generalKallunki Tuulaedt1300030Kallunki TuulaothBOOK9910557648103321Killing Cancer3025349UNINA