04648nam 2201429z- 450 991055764810332120231214132845.0(CKB)5400000000044972(oapen)https://directory.doabooks.org/handle/20.500.12854/69291(EXLCZ)99540000000004497220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierKilling CancerDiscovery and Selection of New Target MoleculesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (302 p.)3-03943-440-3 3-03943-441-1 Despite the efficiency of current cancer treatments, cancer is still a deadly disease for too many. In 2008, 7.6 million people died of cancer; with the current development, it is estimated that the annual cancer death number will grow to 13 million by 2030. There is clearly a need for not only more research but also more innovative and out of the mainstream scientific ideas to discover and develop even better cancer treatments. This book presents the collective works published in the recent Special Issue entitled “Killing Cancer: Discovery and Selection of New Target Molecules”. These articles comprise a selection of studies, ideas, and opinions that aim to facilitate knowledge, thoughts, and discussion about which biological and molecular mechanisms in cancer we should target and how we should target them.Killing Cancer Research & information: generalbicsscBiology, life sciencesbicsscferlinmyoferlindysferlinotoferlinC2 domainplasma membranesulconazoleNF-κBIL-8mammospherebreast cancer stem cellsAF1QMLLT11WNTSTATesophageal cancerprognosismTORC1mTORC2metabolismrapalogsmTOR inhibitorscancer metabolismmTOR in immunotherapynutrient metabolismkinase inhibitorsmTOR signalingMAPK kinaseERK1ERK2CD domainRolledSCH772984VRT-11Esevenmakercancer therapyEMTlysosomelysosome-mediated invasionMZF1phosphorylationPAK4SUMOylationtranscription factorzinc fingerglucocorticoids3D growthnuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB)epithelial-mesenchymal transitionanoikisproliferationtargeted cancer therapydisulfiramNPL4replication stressDNA damageBRCA1BRCA2ATR pathwayPDACTCIRG1ATP6V0a3invasionmigrationmatrix degradationpH-regulationautophagymultidrug resistance in cancerdrug efflux pumpsATP-binding cassette transporterbreast cancer resistance protein (BCRP)ABCG2pyrazolo-pyrimidine derivativeSCO-201colorectal cancerimmunotherapyinflammationmicrosatellite instabilityoncofetal chondroitin sulfatechondroitin sulfatecancersolid tumorstargetpediatric cancerVAR2dexamethasonethyroid cancermicrogravityspace environmentResearch & information: generalBiology, life sciencesKallunki Tuulaedt1300030Kallunki TuulaothBOOK9910557648103321Killing Cancer3025349UNINA