04368nam 2200997z- 450 991055764430332120231214133131.0(CKB)5400000000045010(oapen)https://directory.doabooks.org/handle/20.500.12854/76776(EXLCZ)99540000000004501020202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCrocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic PotentialBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (171 p.)3-0365-1806-1 3-0365-1805-3 Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.Crocus sativus L. Extract and Its ConstituentsMedicinebicsscsaffronaffron®depressionanxietyantioxidantcrocinsglucoseβ-pancreatic cellsinsulinpck1neuroprotective activityP2X7 receptorfractionflumazenilratCrocus sativuscanceranticancer activitychemopreventionclinical trialspatentsanesthetic ketaminememoryCrocus sativus L.schizophreniacrocetinpubertal testisX-raysradiotherapyfertility preservationSIRT1HuRoxidative stressautophagycrocinpicrocrocinsafranaldietary supplementnutraceuticalCrocus sativus L. (Iridaceae)reversed-phase UPLCmetabolomicsHR MSinflammatory bowel diseasegut microbiotacolitiscytokinescolorectal cancerHCT116MLH1MSH3DNA damage and repairapoptosisMedicinePitsikas Nikolaosedt1332364Dimas KonstantinosedtPitsikas NikolaosothDimas KonstantinosothBOOK9910557644303321Crocus sativus L. Extract and Its Constituents: Chemistry, Pharmacology and Therapeutic Potential3040891UNINA