03276nam 2200913z- 450 991055762880332120210501(CKB)5400000000045126(oapen)https://directory.doabooks.org/handle/20.500.12854/69167(oapen)doab69167(EXLCZ)99540000000004512620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierHedgehog Signaling in Organogenesis and Tumor MicroenvironmentBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (172 p.)3-03936-260-7 3-03936-261-5 The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers' drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.Medicinebicsscandrogenanimal experimentarticular discbasement membranebonebone diseasebone morphogenetic proteincancer stem cellscancer-associated fibroblasts (CAFs)chondrocytecongenital anomaliesCRE/LoxPCyp26 enzymesendochondral ossificationepithelial and mesenchymal interactionepithelial-mesenchymal interaction (EMI)external genitaliafracture healingGli1growth platehedgehoghedgehog signalinghedgehog signallinghypospadiasIhhlineage tracing analysismesenchymal stem cellmouse modelsn/aoral squamous cell carcinoma (OSCC)osteoarthritisosteoblastpenisprostate cancerPTHrPretinoic acidsmoothenedsonic hedgehogsonic hedgehog (SHH)stem cellstem cell markersynovial jointTMJtooth developmenttumor microenvironment (TME)tumor-associated angiogenesistumor-associated macrophages (TAMs)urethraMedicineShimo Tsuyoshiedt1297612Shimo TsuyoshiothBOOK9910557628803321Hedgehog Signaling in Organogenesis and Tumor Microenvironment3024614UNINA