03241nam 2200889z- 450 991055762880332120231214133301.0(CKB)5400000000045126(oapen)https://directory.doabooks.org/handle/20.500.12854/69167(EXLCZ)99540000000004512620202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierHedgehog Signaling in Organogenesis and Tumor MicroenvironmentBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (172 p.)3-03936-260-7 3-03936-261-5 The Hedgehog signaling pathway is an evolutionarily conserved pathway that governs complex developmental processes, including stem cell maintenance, proliferation, differentiation, and patterning. Several recent studies have shown that the aberrant activation of Hedgehog signaling is associated with neoplastic transformation, cancer cell proliferation, metastasis, multiple cancers’ drug resistance, and survival rates. This book focuses on several aspects of Hedgehog signaling in organogenesis and the tumor microenvironment, and presents reviews and original papers on recent efforts in the field of Hedgehog signaling.MedicinebicsscCyp26 enzymescongenital anomaliesCRE/LoxPhedgehog signalingmouse modelsretinoic acidsmoothenedsonic hedgehogsonic hedgehog (SHH)oral squamous cell carcinoma (OSCC)tumor microenvironment (TME)tumor-associated macrophages (TAMs)cancer-associated fibroblasts (CAFs)tumor-associated angiogenesishedgehoggrowth plateendochondral ossificationchondrocyteosteoblastbone diseaseTMJsynovial jointarticular discIhhPTHrPosteoarthritisepithelial-mesenchymal interaction (EMI)prostate cancerexternal genitaliaandrogenbasement membranebone morphogenetic proteinstem cellanimal experimentfracture healingcancer stem cellshypospadiasurethrapenisbonehedgehog signallingtooth developmentepithelial and mesenchymal interactionGli1mesenchymal stem celllineage tracing analysisstem cell markerMedicineShimo Tsuyoshiedt1297612Shimo TsuyoshiothBOOK9910557628803321Hedgehog Signaling in Organogenesis and Tumor Microenvironment3024614UNINA