01367nam2-2200397li-450 99000011710020331620180312154858.03-540-16821-40011710USA010011710(ALEPH)000011710USA01001171020001109d1986----km-y0itay0103----baengGWGlobal analysisstudies and applications IIedited by Yu. G. Borisovich and Yu. E. GliklikhBerlin [etc.]Springer-Verlagcopyr. 1986275 p.ill.25 cmLecture notes in mathematics121400100116302001Lecture notes in mathematicsa collection of informal reports and seminarsedited by A. Dold, Heidelberg and B. Eckmann, Zürichanalisi globale51474Analisi globaleBorisovich,Yurii G.Gliklikh,Yurii E.Sistema bibliotecario di Ateneo dell' Università di SalernoRICA990000117100203316510 LNM (1214)0012032 CBS51000110313BKSCI1990091720001110USA011711ALANDI9020011129USA01170220020403USA011619PATRY9020040406USA011609Global analysis79798UNISA03057nam 2200457z- 450 991055762220332120211118(CKB)5400000000045193(oapen)https://directory.doabooks.org/handle/20.500.12854/73716(oapen)doab73716(EXLCZ)99540000000004519320202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCurrent Perspectives, Challenges and Advances in Cell Based TherapiesFrontiers Media SA20201 online resource (192 p.)2-88963-564-3 Cell-based immunotherapy is based on the seemingly simple principle of harnessing the power of the immune system to combat cancer, and is emerging as an important clinical tool. The remarkable success of CAR-T cell therapies demonstrate that cell based therapies are effective at eradicating hematological malignancies, and therefore hold great promise for other cancers. However, there are number of challenges that limit the full potential of cell based therapies, especially for solid cancers. T cells and NK cells represent major lymphocyte populations that are involved in immune surveillance and tumor eradication, and both are emerging as important players for cell based immunotherapy. Although they use different mechanisms for recognizing cancer cells, they complement each other during tumor eradication. NK cells have many functional similarities to T cells and represent the closest innate immune cell lineage to adaptive immune cell populations. Transcriptome analysis has also revealed similar phylogenetic origin of the two lymphocyte populations. The hurdles that impact therapeutic success of these cells include trafficking of lymphocytes to the tumor sites, recognition of solid tumors, and overcoming the inhospitable tumor microenvironment (TME) including the presence of suppressive cells (Treg and MDSC) and immune suppressive cytokines (TGFβ). The full potential of cell based therapies may be realized once tools to overcome these barriers are developed. This Research Topic collects articles critically examining these obstacles and the novel strategies being developed for cell-based therapies to overcome them.Medicine and NursingbicsscOncologybicsscCAR (chimeric antigen receptor) T cellscell based therapyimmunotherapyNK celltumor micoenvironmentMedicine and NursingOncologyTrikha Prashantedt1286917Thakar MonicaedtRussell Cruz ConradedtTrikha PrashantothThakar MonicaothRussell Cruz ConradothBOOK9910557622203321Current Perspectives, Challenges and Advances in Cell Based Therapies3019993UNINA