03147nam 2200745z- 450 991055761510332120220321(CKB)5400000000045251(oapen)https://directory.doabooks.org/handle/20.500.12854/79602(oapen)doab79602(EXLCZ)99540000000004525120202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMonoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.0BaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (112 p.)3-0365-3165-3 3-0365-3164-5 Monoclonal antibodies (mAbs) are among the most specialised molecules for the recognition and capture of specific analytes. Hundreds of thousands of mAbs have been generated for a large number of different antigens with increasing affinity and specificity and are available for the most diverse purposes. Many of them have been validated as irreplaceable agents for diagnosis and therapy or as unique reagents for research. Others have been developed using emerging technologies that avoid the need for animal immunisation. This short book strives to gather the perspective view of the various contributing authors and to survey the new strategic assets adopted to generate novel monoclonal antibodies or surrogates, such as Fab, Fab2, ScFv and nanobodies, which have an increasing impact in biomedicine as therapeutic or diagnostic assets in various diseases.Biology, life sciencesbicsscResearch & information: generalbicsscantibodyatherosclerosisbio-layer interferometryC. auriscandidiasiscell wallcell-based panningcompetitive ELISAepitope identificationexcipientFGFR3-specific antibodyfoot-and-mouth disease virusfree radicalhuman antibodymAbmagnetic resonance imagingmonoclonal antibodiesmonoclonal antibodymultidrug resistancenano-emulsionoxidationpassive immunizationphage displayPRAMEprotein aggregationsemi-automated cell panningstealthtype Atype Ouniversal antibodiesBiology, life sciencesResearch & information: generalRuvo Menottiedt1292387Sandomenico AnnamariaedtRuvo MenottiothSandomenico AnnamariaothBOOK9910557615103321Monoclonal Antibodies and Their Functional Fragments in Research, Diagnosis and Therapy 2.03022242UNINA