04847nam 2201717z- 450 991055761210332120220321(CKB)5400000000045281(oapen)https://directory.doabooks.org/handle/20.500.12854/79644(oapen)doab79644(EXLCZ)99540000000004528120202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvances and Novel Treatment Options in Metastatic MelanomaBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (528 p.)3-0365-3304-4 3-0365-3303-6 The book presents several studies reporting advances on melanoma pathogenesis, diagnosis and therapy. It represents a milestone on the state of the art, updated at 2021, and also presents the current knowledge on the future developments in melanoma field.Medicine and NursingbicsscABT-737acetazolamideacetylcholineadjuvant therapyamoeboid motilityangiogenesisapoptosisarthralgiaBcl-2 familyBCL2L10biomarkersBRAFBRAF inhibitorBRAF inhibitorsBRAF-mutant melanomacancercancer associated fibroblastcancer stem cellscarbonic anhydrasecell therapycheckpoint inhibitorcholinergic systemcombined therapyctDNACXCL10cyclopaminecytokinescytotoxicitydiagnosisDOCK4drug resistanceessential oilsexosomesextracellular vesiclesFAKhedgehogHIPPOHuRimmunityimmunotherapyinterferoninvasionipilimumablactate dehydrogenaselipid metabolismliquid biopsyliver-directed-therapiesmachine learningMANS peptideMARCKSmechanism of actionmelanomamelanoma immune infiltratemelanoma markersmelanoma metastasismelanoma PDXmelanomagenesismetalloproteinasesmetastasesmetastasismetastatic dormancymetastatic therapymetastatic uveal melanoma (mUM)microenvironmentmicroRNAsMITFML258motilitymucosal melanomamuscarinic receptorsn/ananoparticlesnicotinic receptorsnivolumabOXPHOSpatient stratificationPD-1pembrolizumabphosphorylationplasmacytoid dendritic cellspredictionprincipal component analysisprognosisprognosticationprotein tyrosine phosphatasePTPs inhibitorsRac1radiotherapyresistancerheumatoid arthritissex-hormonessex/genderShcD adaptor proteinsiRNAslow cycling phenotypesmall moleculesSOCESTAT3Support Vector Machinesurvivaltarget therapytargeted therapytargeted-therapytherapeutic resistancetherapyTLRTPC2tumor microenvironmenttumour microenvironmentuveal melanoma (UM)WNT5AMedicine and NursingFacchiano Antonioedt1304468Del Bufalo DonatellaedtCarè AlessandraedtFacchiano AntonioothDel Bufalo DonatellaothCarè AlessandraothBOOK9910557612103321Advances and Novel Treatment Options in Metastatic Melanoma3027450UNINA