04786nam 2201693z- 450 991055761210332120231214133000.0(CKB)5400000000045281(oapen)https://directory.doabooks.org/handle/20.500.12854/79644(EXLCZ)99540000000004528120202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAdvances and Novel Treatment Options in Metastatic MelanomaBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (528 p.)3-0365-3304-4 3-0365-3303-6 The book presents several studies reporting advances on melanoma pathogenesis, diagnosis and therapy. It represents a milestone on the state of the art, updated at 2021, and also presents the current knowledge on the future developments in melanoma field.MedicinebicsscmelanomainvasionWNT5AMARCKSphosphorylationMANS peptidenanoparticlescell therapytumor microenvironmentsex/gendersex-hormonesimmunitymicroRNAsimmunotherapyBRAF-mutant melanomaBRAF inhibitormechanism of actiontargeted therapytumour microenvironmentplasmacytoid dendritic cellslactate dehydrogenaseTLRinterferonCXCL10TPC2HIPPOSOCEmetastasisessential oilsangiogenesisapoptosisuveal melanoma (UM)metastatic uveal melanoma (mUM)prognosticationadjuvant therapymetastatic therapymetastatic dormancyliver-directed-therapiestargeted-therapycombined therapyprotein tyrosine phosphatasePTPs inhibitorsmelanoma immune infiltrateBRAF inhibitorsmicroenvironmentresistancetherapytherapeutic resistanceexosomesextracellular vesiclesdiagnosisprognosisctDNAliquid biopsypredictionpatient stratificationBRAFarthralgiarheumatoid arthritiscarbonic anhydrasehedgehogcyclopaminesmall moleculesacetazolamidemotilitymetalloproteinasesFAKcancermucosal melanomanivolumabpembrolizumabipilimumabradiotherapycholinergic systemacetylcholinemuscarinic receptorsnicotinic receptorsmelanoma metastasisShcD adaptor proteinamoeboid motilityRac1DOCK4melanoma PDXtarget therapycancer stem cellsslow cycling phenotypedrug resistanceOXPHOSlipid metabolismcancer associated fibroblastmelanomagenesisbiomarkerscheckpoint inhibitorPD-1melanoma markerscytokinesmachine learningSupport Vector Machineprincipal component analysisBCL2L10STAT3cytotoxicitysurvivalABT-737Bcl-2 familyML258HuRMITFmetastasessiRNAMedicineFacchiano Antonioedt1304468Del Bufalo DonatellaedtCarè AlessandraedtFacchiano AntonioothDel Bufalo DonatellaothCarè AlessandraothBOOK9910557612103321Advances and Novel Treatment Options in Metastatic Melanoma3027450UNINA