04811nam 2201369z- 450 991055760900332120240528190146.0(CKB)5400000000045312(oapen)https://directory.doabooks.org/handle/20.500.12854/79672(EXLCZ)99540000000004531220202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Insights in the Genetics and Genomics of Adrenocortical Tumors and PheochromocytomasBaselMDPI - Multidisciplinary Digital Publishing Institute20221 electronic resource (272 p.)3-0365-3358-3 3-0365-3357-5 This book includes 17 papers published in the Special Issue/Article Collection “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).Medicinebicsscpheochromocytomaparagangliomageneticsnon-coding RNAmalignancybiomarkertreatmentadaptive metabolismadrenal glandconn adenomafatty acid metabolismferroptosishyperaldosteronismmetabolic reprogrammingβ-oxidationPPARαtumor microenvironmentNext Generation Sequencinghereditary cancerendocrine tumor syndromeKCNJ5 somatic mutationpulse wave velocityaldosterone-producing adenomaadrenalectomypropensity score matchingarterial stiffnesspheochromocytomasparagangliomasmutationssusceptibility genesdriver mutationshereditarygermlinesomaticenvironmentvariantstumor suppressor genesmetastaticRNAseqnext generation sequencingadrenocortical carcinomain silico analysismachine learningbioinformatic clusteringbiomarker predictionaldosterone producing adenomaATP2B3K416-F418delinsN mutationprimary aldosteronismPPGLtelomeresTERTATRXNOP10prognostic biomarkerALTphaeochromocytomacancermitochondrial complex IIzebrafishtherapydrug discoveryredox balance pathwayVitamin CmitotaneH295 strainsmicroRNAaldosteronecirculatingadrenocorticaltranscriptomicsepigeneticsmetabolomicsepidemiologygenetic analysismortalitysurveillanceTP53 R337Hgenetic testingadrenocortical tumorneonatal screeningscreeningadenomaadrenaltissueartificial intelligenceneural networkMedicineIgaz Peteredt1082320Igaz PeterothBOOK9910557609003321New Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas3027446UNINA