04848nam 2201393z- 450 991055760900332120220321(CKB)5400000000045312(oapen)https://directory.doabooks.org/handle/20.500.12854/79672(oapen)doab79672(EXLCZ)99540000000004531220202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Insights in the Genetics and Genomics of Adrenocortical Tumors and PheochromocytomasBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (272 p.)3-0365-3358-3 3-0365-3357-5 This book includes 17 papers published in the Special Issue/Article Collectoin "New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas" including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).Medicinebicsscadaptive metabolismadenomaadrenaladrenal glandadrenalectomyadrenocorticaladrenocortical carcinomaadrenocortical tumoraldosteronealdosterone producing adenomaaldosterone-producing adenomaALTarterial stiffnessartificial intelligenceATP2B3ATRXbioinformatic clusteringbiomarkerbiomarker predictioncancercirculatingconn adenomadriver mutationsdrug discoveryendocrine tumor syndromeenvironmentepidemiologyepigeneticsfatty acid metabolismferroptosisgenetic analysisgenetic testinggeneticsgermlineH295 strainshereditaryhereditary cancerhyperaldosteronismin silico analysisK416-F418delinsN mutationKCNJ5 somatic mutationmachine learningmalignancymetabolic reprogrammingmetabolomicsmetastaticmicroRNAmitochondrial complex IImitotanemortalitymutationsn/aneonatal screeningneural networknext generation sequencingNext Generation Sequencingnon-coding RNANOP10paragangliomaparagangliomasphaeochromocytomapheochromocytomapheochromocytomasPPARαPPGLprimary aldosteronismprognostic biomarkerpropensity score matchingpulse wave velocityredox balance pathwayRNAseqscreeningsomaticsurveillancesusceptibility genestelomeresTERTtherapytissueTP53 R337Htranscriptomicstreatmenttumor microenvironmenttumor suppressor genesvariantsVitamin Czebrafishβ-oxidationMedicineIgaz Peteredt1082320Igaz PeterothBOOK9910557609003321New Insights in the Genetics and Genomics of Adrenocortical Tumors and Pheochromocytomas3027446UNINA