03302nam 2200757z- 450 991055760860332120220321(CKB)5400000000045316(oapen)https://directory.doabooks.org/handle/20.500.12854/79675(oapen)doab79675(EXLCZ)99540000000004531620202203d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierChronic HCV Infection: Clinical Advances and Eradication PerspectivesBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (104 p.)3-0365-3361-3 3-0365-3362-1 Hepatitis C virus (HCV) chronic infection can determine liver fibrosis, cirrhosis and hepatocellular carcinoma, as well as several extra-hepatic manifestations (i.e., mixed cryoglobulinemia, metabolic syndrome, kidney disease, etc.). HCV infection is asymptomatic until severe stages of disease, thus screening policy in the general population and in specific risk categories is necessary to allow for timely intervention. Despite a high sustained virological response by direct-acting antiviral drugs, a limited percentage of treated subject failed therapy according to resistance associated substitution carried on viral isolates and comorbidities in infected patients. Therefore, tailored therapy is required to cure HCV infection. Failure to comply with these conditions may impair success of HCV eradication expected by 2030. This Special Issue aims to discuss eradication perspectives related to therapy efficacy in patients with chronic diseases, developments in diagnostic procedures and improvements in screening policy.Chronic HCV InfectionEpidemiology and Medical statisticsbicsscMedicine and Nursingbicsscchildrenchronic hepatitis CCOVID-19direct-acting antiviralseliminationfibrosisgenotype 3HCVHCV eradicationhepatitis Chepatitis C virus (HCV)hepatocellular carcinomahomeless personsinterferonledipasvir/sofosbuvirliver cirrhosismodelmortalityn/aout-of-hospitalpangenotypicphylogenyPWIDreal-liferesistance-associated substitution (RAS)retention in carerheumaticsteatosissustained virological responsevibration controlled transient elastographyEpidemiology and Medical statisticsMedicine and NursingLiberto Maria Carlaedt1302761Marascio NadiaedtLiberto Maria CarlaothMarascio NadiaothBOOK9910557608603321Chronic HCV Infection: Clinical Advances and Eradication Perspectives3026524UNINA