04209nam 2201165z- 450 991055760030332120210501(CKB)5400000000043674(oapen)https://directory.doabooks.org/handle/20.500.12854/68319(oapen)doab68319(EXLCZ)99540000000004367420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAggregatibacter actinomycetemcomitans-Gram-Negative Bacterial PathogenBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (232 p.)3-03943-376-8 3-03943-377-6 Aggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence potential of the isolated bacteria, genetic profiling is recommended. Advanced knowledge of the virulence mechanisms induced by this bacterium is important for the development of future personalized preventive and treatment strategies. The fifteen papers in this book provide a strong and relevant background that can contribute to the improvement of future diagnosis and research strategies.Biology, life sciencesbicsscResearch and information: generalbicsscA. actinomycetemcomitansaccessory genesadherenceadjunctive antibioticsAggregatibacter actinomycetemcomitansantimicrobial activityapoptosisaverage nucleotide identitybacteremiabiofilmcagEcell lysis assaycore and accessory genescore genescytokine binding factorscytolethal distending toxincytotoxicitydamage/response frameworkdifferentially expressed genes.endocarditisendocytosisessential oilfimbriaegenomic islandsgenotypehorizontal gene transferhorseshoe crabimmune responseinflammasomeJP2JP2 clone of Aggregatibacter actinomycetemcomitansJP2 genotypeJP2 in Caucasiankeratinslandscape ecologyleukotoxinleukotoxin (LtxA)leukotoxin neutralizationLFA-1lipopolysaccharideslocalized aggressive periodontitislocalized aggressive periodontitis: animal studies: human studieslymphocytesmicrobiological diagnosisminimal bactericidal concentrationminimum inhibitory concentrationmRNA assayn/anutrient limitationorganotypic gingival mucosaOriganum vulgareouter membrane vesiclesperiodontal diseaseperiodontitisprincipal component analysisproteomicproteomicsquantitative ELISARNA-SeqRTX toxinstresstaxonomyvirB1virB4virulenceBiology, life sciencesResearch and information: generalJohansson Andersedt1161470DiRienzo Joseph MedtJohansson AndersothDiRienzo Joseph MothBOOK9910557600303321Aggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen3019562UNINA