04168nam 2201141z- 450 991055760030332120231214133342.0(CKB)5400000000043674(oapen)https://directory.doabooks.org/handle/20.500.12854/68319(EXLCZ)99540000000004367420202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAggregatibacter actinomycetemcomitans-Gram-Negative Bacterial PathogenBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (232 p.)3-03943-376-8 3-03943-377-6 Aggregatibacter actinomycetemcomitans is a well-studied Gram-negative bacterium that can often be found in the oral cavity of young individuals. It has several virulence factors and a large genetic diversity, which results in both harmless and highly virulent genotypes. To determine the virulence potential of the isolated bacteria, genetic profiling is recommended. Advanced knowledge of the virulence mechanisms induced by this bacterium is important for the development of future personalized preventive and treatment strategies. The fifteen papers in this book provide a strong and relevant background that can contribute to the improvement of future diagnosis and research strategies.Research & information: generalbicsscBiology, life sciencesbicsscAggregatibacter actinomycetemcomitanscagEvirB1virB4genotypevirulencemRNA assayquantitative ELISAcell lysis assayleukotoxinJP2 genotypecytolethal distending toxinlipopolysaccharidescytokine binding factorshorizontal gene transferouter membrane vesiclesbiofilmproteomicadherenceendocarditisfimbriaeJP2periodontitistaxonomycore and accessory genesaverage nucleotide identityprincipal component analysiskeratinsorganotypic gingival mucosaA. actinomycetemcomitansRNA-Seqgenomic islandscore genesaccessory genesstressnutrient limitationdifferentially expressed genes.lymphocytesapoptosisRTX toxinlocalized aggressive periodontitisLFA-1leukotoxin (LtxA)endocytosisJP2 clone of Aggregatibacter actinomycetemcomitansJP2 in Caucasianmicrobiological diagnosisadjunctive antibioticslocalized aggressive periodontitis: animal studies: human studieslandscape ecologydamage/response frameworkbacteremiahorseshoe crabOriganum vulgareessential oilantimicrobial activityminimum inhibitory concentrationminimal bactericidal concentrationcytotoxicityleukotoxin neutralizationinflammasomeimmune responseperiodontal diseaseproteomicsResearch & information: generalBiology, life sciencesJohansson Andersedt1161470DiRienzo Joseph MedtJohansson AndersothDiRienzo Joseph MothBOOK9910557600303321Aggregatibacter actinomycetemcomitans-Gram-Negative Bacterial Pathogen3019562UNINA