00993cam0 22002893 450 SOB00383620121024115215.0847039457620040211d1986 |||||ita|0103 baspaSPJuanita la LargaJuan Valeraedición, introducción y notas de Enrique RubioMadridEditorial Castalia1986300 p.ill.18 cmClásicos Castalia141001LAEC000159052001 *Clásicos Castalia141Valera, JuanAF00005242070291014Rubio_Cremades, EnriqueAF00012490070ITUNISOB20121024RICAUNISOBUNISOB860|Coll|3|K104158SOB003836M 102 Monografia moderna SBNM860|Coll|3|K000141SI104158acquistoNcarranoUNISOBUNISOB20120322124557.020121024115017.0vittoriniJuanita la Larga102425UNISOB01169cam a2200277 i 4500991000271689707536090604s1999 gb 00 eng d0198773129b13834368-39ule_instSet. Economia - SEMSita530.01Bauwens, Luc323257Bayesian inference in dynamic econometric models /Luc Bauwens, Michel Lubrano and Jean-François RichardOxford [etc.] :Oxford University Press,1999xv, 350 p. ;24 cmAdvanced texts in econometricsReferences: p. 323-339Inferenza statisticaTeoria bayesianaApplicazioni all'econometriaLubrano, Michelauthorhttp://id.loc.gov/vocabulary/relators/aut119307Richard, Jean-François.b1383436802-04-1404-06-09991000271689707536LE025 ECO 530.01 BAU01.0112025000250369le025-E0.00-lm 011510.i1497670504-06-09Bayesian inference in dynamic econometric models1440223UNISALENTOle02504-06-09ma -enggb 0004352nam 2200985z- 450 991055759560332120220111(CKB)5400000000043721(oapen)https://directory.doabooks.org/handle/20.500.12854/76802(oapen)doab76802(EXLCZ)99540000000004372120202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMarine Natural Products as Anticancer AgentsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (150 p.)3-0365-1820-7 3-0365-1819-3 Cancer remains one of the most significant threats to human health and one of the deadliest diseases worldwide, making it crucial to develop new drugs. Over the last few decades, natural products have become one of the key drivers in the development of innovative cancer treatments. Despite drug development from terrestrial resources, the marine environment only recently emerged as a prolific source of unparalleled structurally active metabolites. Due to their excellent scaffold diversity, structural complexity, and ability to act on multiple cell signaling networks involved in carcinogenesis, marine natural products (MNPs) are ideal candidates to inspire the development of novel anticancer medicines. This book gathers nine publications of the Special Issue "Marine Natural Products as Anticancer Agents," providing an excellent overview of the chemical richness offered by marine organisms, such as sponges, myxobacteria, fungi, and soft corals. MNPs or derived products belong to distinct chemical classes, including terpenoids, alkaloids, cyclodepsipeptides, polyketides, and hydroxyphenylacetic acid derivatives. These compounds modulate cancer cell mechanisms in in vitro and in vivo models, exhibiting high specificity and great affinity to interact with biological targets linked to specific intracellular signaling pathways, including mitochondrial dysfunction, autophagy, endoplasmic reticulum stress induction, apoptosis, inflammation, migration, and invasion. This volume provides an exciting overview of marine natural products as potential therapeutic agents for cancer treatment.Medicine and Nursingbicsscalgaanti-cancerantitumoraplysinopsin analogsapoptosisastaxanthinBH3 mimeticsbioactive compoundsbiscembranoid-type metabolitesBT20cancer stem cellscancer therapychronic myeloid leukemiacolony formationcytotoxicityEhlich's tumorenvironmentepigenetic signalingepigenomeepithelial-mesenchymal transitionflaccidoxide-13-acetategram-scalehepatocellular carcinomahydroxyphenylacetic acidindole alkaloidsinflammationinflammatory factor productioninvasionLPS-stimulated murine macrophagemarine sourcemarine speciesmarine-derived fungusmeroterpenoidsmigrationmutp53n/anannocystinNanognatural productOct4P. purpurogenumPenicillium chrysogenumpolyketidepontinproliferationprostate cancerSarcophyton digitatumsecondary metabolitessiRNASTAT3T47Dtotal synthesisMedicine and NursingAlves Celsoedt1304461Diederich MarcedtAlves CelsoothDiederich MarcothBOOK9910557595603321Marine Natural Products as Anticancer Agents3027442UNINA