06882nam 2201981z- 450 991055757720332120210501(CKB)5400000000043877(oapen)https://directory.doabooks.org/handle/20.500.12854/69023(oapen)doab69023(EXLCZ)99540000000004387720202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitochondria in Health and DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (434 p.)3-03936-384-0 3-03936-385-9 Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.Medicine and Nursingbicssc2-oxoglutarate dehydrogenase4-HNEadenine nucleotide translocaseADP/ATP carrieragingamino acid neurotransmitterancient mutationantioxidant systemantioxidantsapoptosisBAXBCL-2BKCa channelscardiolipincardiomyocytescardioprotectioncerebellar amino acid metabolismcholangiocellular carcinomacoloncomplex I (CI) deficiencycyclosporin Acytoskeletal proteinsDDEdentate granule celldevelopmentdextranDRP1dsRNAelectron and confocal microscopyelectron tunneling (ET)energy metabolismepilepsyERK1/2ETC complexesfatty acid oxidationferritingemfibrozilGW9662H9c2 cardiomyoblastshealthy cellshearthepatic fibrogenesishepcidinhigh-fat diethippocampusHtrA2/Omihuman amniotic membranehuman diseaseshyperforinhypoglycemiahypoxiainflammationinnate immunityinorganic phosphateinterferon responseintranuclear mitochondriaion homeostasisiron overloadischemia reperfusion injuryJNKKmADPLangendorffLHONlife spanlipid dropletlipid handlingliverLONP1metabolome and proteome profilingmitochondriamitochondria bioenergeticsmitochondria calcium bufferingmitochondria permeability transition poremitochondria: energy metabolismmitochondrial cell deathmitochondrial connexin 43mitochondrial dynamicsmitochondrial dysfunctionmitochondrial functionmitochondrial gene expressionmitochondrial homeostasismitochondrial interactionsmitochondrial permeability transition poresmitochondrial UCP2morphologymtDNAmtDNA transcriptionmtRNAmuscle agingmyocardialneuron deathneuroprotectionoxidative phosphorylationoxidative stressperilipin 5physical performancepilocarpinepioglitazonePKAplectinpost-transcriptional mtRNA processingpotassium channelpravastatinprotein phosphatasespyruvate dehydrogenasepyruvate dehydrogenase kinasereactive oxygen speciesreactive oxygen species (ROS)reactive oxygen species stressredox stateregenerationrespirasome assemblyrespiratory supercomplexesROSrosiglitazoneseizureSiberian populationsignalingsignaling pathwayssiRNAsodium dichloroacetatespecific genetic backgroundtelomerase activitytelomere lengthtensile strengthtransferrintricarboxylic acid cycletubulin betaTUNELTZDuncouplinguncoupling proteinZIPMedicine and NursingJavadov Sabzaliedt1280541Kozlov Andrey VedtCamara Amadou K.SedtJavadov SabzaliothKozlov Andrey VothCamara Amadou K.SothBOOK9910557577203321Mitochondria in Health and Diseases3017189UNINA