06841nam 2201969z- 450 991055757720332120231214132952.0(CKB)5400000000043877(oapen)https://directory.doabooks.org/handle/20.500.12854/69023(EXLCZ)99540000000004387720202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierMitochondria in Health and DiseasesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (434 p.)3-03936-384-0 3-03936-385-9 Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.Medicinebicsschypoglycemiasodium dichloroacetatepyruvate dehydrogenase kinasepyruvate dehydrogenaseoxidative stressneuron deathcholangiocellular carcinomamitochondriaenergy metabolismoxidative phosphorylation4-HNEDRP1ERK1/2hippocampusJNKmitochondrial dynamicsPKAprotein phosphatasesTUNELDDEhigh-fat dietmitochondrial UCP2ROSantioxidant systemuncoupling proteinmitochondria: energy metabolismlipid handlingfatty acid oxidationpotassium channelreactive oxygen speciesantioxidantslife spanagingBKCa channelspravastatingemfibrozillivercolonmitochondrial functioncyclosporin Amitochondria calcium bufferingmitochondria bioenergeticsmitochondria permeability transition poreinorganic phosphatehepatic fibrogenesisHtrA2/Omireactive oxygen species stressmitochondrial homeostasiscomplex I (CI) deficiencymetabolome and proteome profilingreactive oxygen species (ROS)respirasome assemblyelectron tunneling (ET)perilipin 5lipid dropletH9c2 cardiomyoblastsadenine nucleotide translocaserespiratory supercomplexesETC complexesdentate granule cellepilepsyhyperforinLONP1neuroprotectionpilocarpineseizuresiRNAcardioprotectionmitochondrial permeability transition poresmitochondrial connexin 43cardiolipiniron overloadhepcidintransferrinferritinZIPinflammationmtDNAmitochondrial dysfunctionmuscle agingphysical performanceLHONSiberian populationancient mutationspecific genetic backgroundapoptosishuman amniotic membranemitochondrial cell deathBAXBCL-2tensile strengthmitochondrial gene expressionmtDNA transcriptionmtRNApost-transcriptional mtRNA processingdsRNAinnate immunityinterferon responseamino acid neurotransmittercerebellar amino acid metabolismhypoxia2-oxoglutarate dehydrogenasetricarboxylic acid cycleheartcytoskeletal proteinsmitochondrial interactionsplectintubulin betasignalingGW9662ischemia reperfusion injuryLangendorffmyocardialpioglitazoneredox staterosiglitazoneTZDuncouplingADP/ATP carrierKmADPdextranmorphologycardiomyocytestelomere lengthtelomerase activitydevelopmentregenerationintranuclear mitochondriahealthy cellselectron and confocal microscopysignaling pathwaysion homeostasishuman diseasesMedicineJavadov Sabzaliedt1280541Kozlov Andrey VedtCamara Amadou K.SedtJavadov SabzaliothKozlov Andrey VothCamara Amadou K.SothBOOK9910557577203321Mitochondria in Health and Diseases3017189UNINA