06798nam 2201873z- 450 991055757700332120220111(CKB)5400000000043879(oapen)https://directory.doabooks.org/handle/20.500.12854/77168(oapen)doab77168(EXLCZ)99540000000004387920202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCoumarin and Its DerivativesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (406 p.)3-0365-2775-3 3-0365-2774-5 Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.Biology, life sciencesbicsscResearch & information: generalbicssc3-aroylcoumarines4-hydroxy-7-methoxycoumarin4-hydroxycoumarin6'-(4-biphenyl)-β-iso-cinchonineacenocoumaroladenosine receptorsanalytical methodsanti-HIVantibacterial activityanticancer activityanticoagulationantiplatelet activityapoptosisautophagybenzopyronesbenzyl 2,3-butadienoatebinding affinitybioactivitybiological applicationsbiosynthesisbiotransformationcalanolide AcalanolidesCalophyllaceaeCalophyllumchalcocoumarinchalconechalepensinchalepincharge transfercholinesterase inhibitioncholinesterasesChromobacterium violaceumcomplementary therapiesconstitutive androstane receptorcoumarincoumarin dyescoumarin3-carboxamidescoumarinsCOXCrohn's diseasecurcumincurcumin-coumarin hybridsdihydrocoumarin-fused dihydropyranonesdirect laser writedockingdocking simulationdrug discoverydye-sensitized solar cellselectrophilic compoundsEscherichia coliesculetinesculinethynylarylferulenolfive-membered aromatic heterocyclesfluorescent probesfree radical polymerizationfuranglutathioneglycyrolGlycyrrhiza uralensishuman monoamine oxidaseshydroxyl-modified coumarinimidazoleimmunoproteasomeimpedance aggregometryin silico studiesin silico toolsinflammationinflammatory bowel diseaseintestinal inflammationisocoumarinkineticsLEDliquiritigeninmacrophageMAO-BMAPKmechanical valvemodel plantmolecular dynamicsmonoamine oxidase inhibitionn/anatural genetic variationnatural productsneurodegenerative diseasesneuroprotectionNF-κBnon-nucleoside reverse transcriptase inhibitors (NNRTIs)non-peptidicostholeoxazoleoxidative stressphotocompositesphotophysicalplant-derived moleculespolyphenolspseudocalanolidespsoralen corepyranocoumarinspyrazolepyrroleQS inhibitorsquorum sensingreverse transcriptaseRuta chalepensisRutaceaescavenging activityscoparoneselenophensimple coumarinssorafenibstructural annotationthermal and structural characterizationthiadiazolethiazolethieno [3,2-b] thiophenethiophenetime in therapeutic rangetriazoleulcerative colitisumbelliferonewarfarinwarhead scanYin Chen HaoBiology, life sciencesResearch & information: generalMatos Maria Joãoedt1297538Matos Maria JoãoothBOOK9910557577003321Coumarin and Its Derivatives3024513UNINA