06761nam 2201849z- 450 991055757700332120231214133002.0(CKB)5400000000043879(oapen)https://directory.doabooks.org/handle/20.500.12854/77168(EXLCZ)99540000000004387920202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierCoumarin and Its DerivativesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (406 p.)3-0365-2775-3 3-0365-2774-5 Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.Research & information: generalbicsscBiology, life sciencesbicssccoumarinhydroxyl-modified coumarinphotophysicalthermal and structural characterizationGlycyrrhiza uralensisglycyrolliquiritigenincholinesteraseshuman monoamine oxidaseskineticsdocking simulationchalconeneurodegenerative diseasesadenosine receptorsbinding affinitydocking4-hydroxy-7-methoxycoumarinmacrophageinflammationNF-κBMAPKcalanolidespseudocalanolidescalanolide ACalophyllumCalophyllaceaeanti-HIVreverse transcriptasenon-nucleoside reverse transcriptase inhibitors (NNRTIs)ostholeumbelliferoneesculin4-hydroxycoumarinsorafenibapoptosisautophagyYin Chen Haoconstitutive androstane receptorscoparonecoumarinsquorum sensingQS inhibitorsplant-derived moleculesChromobacterium violaceumimmunoproteasomepsoralen corenon-peptidicelectrophilic compoundswarhead scaninflammatory bowel diseaseisocoumarinCrohn's diseaseulcerative colitisglutathioneoxidative stresscomplementary therapiesintestinal inflammationbenzopyronesfive-membered aromatic heterocyclesfuranpyrrolethiopheneselenophendihydrocoumarin-fused dihydropyranones3-aroylcoumarinesbenzyl 2,3-butadienoate6'-(4-biphenyl)-β-iso-cinchoninebiological applicationsdrug discoveryfluorescent probeswarfarinacenocoumarolmechanical valvetime in therapeutic rangeanticoagulationRuta chalepensisRutaceaechalepinchalepensinbioactivitybiosynthesiscoumarin3-carboxamidespyranocoumarinsanticancer activityantibacterial activityfree radical polymerizationLEDphotocompositesdirect laser writeanalytical methodsmodel plantnatural genetic variationnatural productssimple coumarinschalcocoumarinMAO-Bmolecular dynamicsin silico studiesdye-sensitized solar cellscoumarin dyesthieno [3,2-b] thiophenecharge transferethynylarylesculetinantiplatelet activityimpedance aggregometryCOXpolyphenolspyrazoleimidazolethiazoleoxazoletriazolethiadiazolecurcumincurcumin-coumarin hybridsneuroprotectionmonoamine oxidase inhibitioncholinesterase inhibitionscavenging activityEscherichia colibiotransformationferulenolstructural annotationin silico toolsResearch & information: generalBiology, life sciencesMatos Maria Joãoedt1297538Matos Maria JoãoothBOOK9910557577003321Coumarin and Its Derivatives3024513UNINA