00765nam0-22002771i-450-99000034678040332120050614105326.0000034678FED01000034678(Aleph)000034678FED0100003467820020821d1967----km-y0itay50------baitay-------001yyFacoltà di ingegneria 1947-1967Università degli studi di BariBariDedalo1967181 p.30 cm378Università degli studi di Bari19817ITUNINARICAUNIMARCBK99000034678040332104 220-11CIDINCHDINCHFacoltà di ingegneria 1947-1967125367UNINA04909nam 2201093z- 450 991055757690332120210501(CKB)5400000000043880(oapen)https://directory.doabooks.org/handle/20.500.12854/68663(oapen)doab68663(EXLCZ)99540000000004388020202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Horizons in Time-Domain Diffuse Optical Spectroscopy and ImagingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (246 p.)3-03936-100-7 3-03936-101-5 Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer-Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.Medicine and NursingbicsscNeurosciencesbicssc3-hour sittingabsorptionagingbiological tissuebrainbrain atrophybrain oxygenationbreast cancercerebral blood volumecerebral hemoglobin oxygen saturationcharacteristic length and time scales of photon transportchemotherapycircumferencecognitive functioncompression stockingdatatypesdiffuse lightdiffuse optical spectroscopydiffuse optical tomographydiffuse opticsdiffusion and delta-Eddington approximationsdiffusion approximationdiffusion equationextracellular waterfluorescence diffuse optical tomographygastrocnemiushemoglobinhighly forward scattering of photonsintracellular waterinverse probleminverse problemslight propagation in tissuemagnetic resonance imagingn/anear infrared spectroscopynear infrared time-resolved spectroscopynear-infrared spectroscopynear-infrared time-resolved spectroscopyneonateNIRSnoninvasivenull source-detector separationoptical pathlengthoptical properties of tissueoptical tomographyprefrontal cortexradiative transfer equationscatteringsubcutaneous white adipose tissuetime-domaintime-domain instrumentstime-domain NIRStime-domain spectroscopytime-resolvedtime-resolved spectroscopytissue oxygenationtissue saturationtissue total hemoglobinTRSvaginal deliveryVSRADMedicine and NursingNeurosciencesHoshi Yokoedt1328681Hoshi YokoothBOOK9910557576903321New Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging3038818UNINA