04849nam 2201069z- 450 991055757690332120231214132957.0(CKB)5400000000043880(oapen)https://directory.doabooks.org/handle/20.500.12854/68663(EXLCZ)99540000000004388020202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierNew Horizons in Time-Domain Diffuse Optical Spectroscopy and ImagingBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (246 p.)3-03936-100-7 3-03936-101-5 Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.MedicinebicsscNeurosciencesbicsscbreast cancerdiffuse optical spectroscopychemotherapytime-domain spectroscopynear-infrared spectroscopyradiative transfer equationdiffusion equationbiological tissuetime-domain instrumentslight propagation in tissueoptical properties of tissuediffuse optical tomographyfluorescence diffuse optical tomographytime-resolved spectroscopyNIRSdiffuse opticstime-domaintime-resolvedbrain oxygenationtissue saturationscatteringabsorption3-hour sittingnear infrared time-resolved spectroscopycompression stockingtissue oxygenationextracellular waterintracellular watercircumferencegastrocnemiusneonatevaginal deliverycerebral blood volumecerebral hemoglobin oxygen saturationnear-infrared time-resolved spectroscopynear infrared spectroscopyagingprefrontal cortexTRSmagnetic resonance imagingbrain atrophyVSRADoptical pathlengthhemoglobincognitive functiontime-domain NIRSnull source-detector separationbrainnoninvasivesubcutaneous white adipose tissuetissue total hemoglobindiffuse lightinverse problemsoptical tomographyinverse problemdatatypesdiffusion approximationhighly forward scattering of photonsdiffusion and delta-Eddington approximationscharacteristic length and time scales of photon transportMedicineNeurosciencesHoshi Yokoedt1328681Hoshi YokoothBOOK9910557576903321New Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging3038818UNINA