08179nam 2202581z- 450 991055753130332120240125182826.0(CKB)5400000000044265(oapen)https://directory.doabooks.org/handle/20.500.12854/69110(EXLCZ)99540000000004426520202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAntitumoral Properties of Natural ProductsVolume 2Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (300 p.)3-03943-114-5 3-03943-115-3 Cancer is one of the major causes of death worldwide. It is a multifactorial heterogeneous disease characterized by the transformation of normal cells into malignant cells, which acquire an uncontrolled growth, immortality, invasiveness, and ability to form distant metastasis. Natural bioactive molecules may interfere with these processes and inhibit the carcinogenesis process. In this book, new molecules and extracts, mainly derived from plants, have been described as being able to alter tumor cell behavior and target several abnormal molecular pathways in cancer cells. Among different cancer cells, the more studied include those derived from glioblastoma, osteosarcoma, lung, breast and gastric cancer. These natural products could be an attractive source for the development of new preventative and therapeutic agents against cancer. They may be more selective and have weaker adverse effects compared to conventional chemotherapy drugs that are actually used for cancer treatment. Clinical trials are necessary to demonstrate whether the in vitro and in vivo animal data are reproduced in humans before the application of natural products in cancer prevention and treatment.Antitumoral Properties of Natural ProductsResearch & information: generalbicsscBiology, life sciencesbicssccytotoxic activityNCI-60 cancer cell linepristimerinSalacia crassifoliaCelastraceaeBrazilian Cerrado biomeSalacia ellipticaCheiloclinium cognatumPlenckia populneaAspergillus fumigatusCordyceps sinensisisochromaneschiral resolutionECD calculationcytotoxicitycoronarin DJNKosteosarcomaZeylenonegastric cancerinvasionmigrationapoptosisanti-cancer agentsanthraquinonesglycosyltransferaseDendrobium officinalestructure elucidationanti-tumor activityplantation modeARGanoderma tsugaelipogenesisprostate cancerSREBP-1ursolic acidbetulinic acidtriterpenoidsnecroticquercetinquercetagetinpatuletinlichensecondary metabolitestumidulinstemness potentialcolorectal cancer cellsoncogenetranscriptional regulationneferineFAK/S6K1autophagyhuman neuroblastoma cellsnatural yellow Monascus pigmentswater-solubleantioxidationMCF-7 cellsphloretincell proliferationinflammationglucose uptakeCatalpa speciosaTaxus cuspidataMagnolia acuminataphenolsantioxidantsanticancerColocasia esculentafood bioactivetarinstable nanocapsulesentrapment efficiencyno-toxicitypreclinical testsantitumoral activitychemotherapeutic adjuvantgrape leavesASETPAntioxidant activitiesAntiproliferativepro-apoptotic effectsGene expressionNutraceuticalsCucurbitacin Bgefitinib-resistant NSCLCEGFRlysosomal degradationCIP2AzerumbonecancerNF-κBIL-6/JAK2/STAT3AktFOXO1multiple myelomaquality controlnaringeninflavonoidstraditional preparationcancer stem cellsphytochemicalsplant-derived foodsfruitvegetablecell signalingArtemisia absinthiumendoplasmic reticulum stressmitochondrial-dependent pathwaymelanomabee venommelittintemozolomideAKTMAPKantrodin CmTORmetabolic stabilitycapsazepineinflammatory diseasesROSTRPV1PI3K/AKT/mTORCLE-10LC3MDA-MB-231lactoferrin hydrolysatecoppermanganesegastric cancer cellsanti-cancer activitymolecular mechanismnatural product alkaloidscephalotaxineprotein synthesis inhibitionantiproliferation agentsfolk medicineDLD-1 cellsdoxorubicinchemotherapydrug resistanceCrataBLglioblastomamesenchymal stem cellsmicroenvironmentplant lectinprotease inhibitorcryptolepineneocryptolepineisocryptolepineantiproliferative activitystructure activity relationshipsLicochalcone AATM-Chk213-ethylberberinemitochondrial ROSRT-R breast cancer cellsdiallyl disulfidePI3K/Akt/mTOR pathwayPulsatilla saponin DSB365glioblastoma multiformeautophagic flux inhibitionlysosomal membrane permeabilizationmitochondrial membrane potentialCLEFMAp38proanthocyaninsTNF-αlung adenocarcinomanatural compoundscervical cancercell cycle arrestdicentrinemetastasisgliomasemi-synthetic derivativeingenolEuphorbia tirucalliprotein kinase Cseaweedporphyrancarrageenananti-cancernatural productsResearch & information: generalBiology, life sciencesFabiani Robertoedt1314851Fabiani RobertoothBOOK9910557531303321Antitumoral Properties of Natural Products3032047UNINA