05541nam 2201417z- 450 991055752760332120220111(CKB)5400000000044302(oapen)https://directory.doabooks.org/handle/20.500.12854/76325(oapen)doab76325(EXLCZ)99540000000004430220202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPlasma in Cancer TreatmentBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (358 p.)3-0365-1209-8 3-0365-1208-X In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments-such as immunotherapy-to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP-such as 3D in vitro, in ovo, and in vivo models and in silico approaches-as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.Medicine and Nursingbicsscanticancer drugsapoptosisbone cancerbreast cancercancercancer selectivitycell adhesioncell communicationcellular uptakecervical cancer treatmentcervical intraepithelial neoplasiacervical intraepithelial neoplasia (CIN)cholangiocarcinomacold atmospheric plasmacold atmospheric plasma (CAP)cold atmospheric pressure plasmacold physical plasmacold plasmacombination therapycommunication junctionscytotoxicitydendritic cellsdielectric barrier dischargeDNA-damageelectric pulseselectroporationextracellular matrix (ECM)extracellular vesiclesfree radicalsgenome-wide expressiongold quantum dotshigh frequency electrosurgeryhuman glioblastomaimmunogenic cell deathindirect treatmentinnovative therapyinvasivenesskINPenlong-lived reactive oxygen and nitrogen specieslong-lived reactive speciesmacrophagesmelanomamulticellular tumor spheroidsn/ananomaterialsnon-invasive plasma treatment (NIPP)non-thermal atmospheric pressure plasma (NTP)non-thermal plasmanonthermal biocompatible plasmaolapariboncologyorganotypic modelosteosarcomaovarian cancerp38/MAPK pathwaypancreatic cancerpancreatic stellate cellsPARP-inhibitorplasmaplasma jetPlasma lipid interactionsplasma medicineplasma selectivityplasma treatmentplasma-activated liquidplasma-activated liquidsplasma-activated Ringer's lactate solutionplasma-treated liquidplasma-treated phosphate-buffered salinepulsed electric field amplituderadiation therapyradio-frequency dischargeRaman imagingRaman microspectroscopyreactive oxygen and nitrogen speciesreactive oxygen and nitrogen species (ROS)reactive oxygen speciesreactive speciesRinger's salineROSscreeningselectivitysoft jet plasmathree-dimensional in vitro culture modelstissue penetrationtumor cellstumor spheroidstumour microenvironment (TME)Medicine and NursingBogaerts Annemieedt1312704Privat-Maldonado AngelaedtBogaerts AnnemieothPrivat-Maldonado AngelaothBOOK9910557527603321Plasma in Cancer Treatment3030934UNINA