05488nam 2201393z- 450 991055752760332120231214133331.0(CKB)5400000000044302(oapen)https://directory.doabooks.org/handle/20.500.12854/76325(EXLCZ)99540000000004430220202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPlasma in Cancer TreatmentBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (358 p.)3-0365-1209-8 3-0365-1208-X In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.Medicinebicssccell adhesionplasma medicineoncologycold atmospheric plasmaselectivityplasma-treated liquiddielectric barrier dischargepancreatic cancerpancreatic stellate cellsimmunogenic cell deathdendritic cellscell communicationextracellular matrix (ECM)reactive oxygen and nitrogen species (ROS)tumour microenvironment (TME)extracellular vesiclescommunication junctionsthree-dimensional in vitro culture modelsapoptosisbreast cancergenome-wide expressionreactive oxygen speciesanticancer drugsscreeningtumor spheroidscombination therapykINPenreactive oxygen and nitrogen speciesROScancernon-thermal atmospheric pressure plasma (NTP)indirect treatmentplasma-treated phosphate-buffered salineelectroporationelectric pulsespulsed electric field amplitudemelanomalong-lived reactive speciesbone cancerosteosarcomareactive speciesplasma-activated liquidRinger's salineorganotypic modelnonthermal biocompatible plasmasoft jet plasmahuman glioblastomap38/MAPK pathwaytissue penetrationnon-thermal plasmanon-invasive plasma treatment (NIPP)cervical intraepithelial neoplasia (CIN)Raman imagingRaman microspectroscopyPlasma lipid interactionscold physical plasmaradiation therapyradio-frequency dischargePARP-inhibitorolaparibDNA-damagegold quantum dotsplasmananomaterialscellular uptakeinvasivenesscold atmospheric pressure plasmaplasma-activated Ringer's lactate solutionovarian cancercytotoxicityplasma-activated liquidsmulticellular tumor spheroidslong-lived reactive oxygen and nitrogen specieshigh frequency electrosurgeryplasma treatmentcold atmospheric plasma (CAP)free radicalscancer selectivitycervical cancer treatmentcervical intraepithelial neoplasiacholangiocarcinomacold plasmainnovative therapytumor cellsmacrophagesplasma selectivityplasma jetMedicineBogaerts Annemieedt1312704Privat-Maldonado AngelaedtBogaerts AnnemieothPrivat-Maldonado AngelaothBOOK9910557527603321Plasma in Cancer Treatment3030934UNINA