06275nam 2201777z- 450 991055751950332120231214133221.0(CKB)5400000000044384(oapen)https://directory.doabooks.org/handle/20.500.12854/77009(EXLCZ)99540000000004438420202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAppetite and Satiety Control-Gut MechanismsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (454 p.)3-0365-2348-0 3-0365-2347-2 The prevalence of obesity and its comorbidities, particularly type 2 diabetes, cardiovascular and hepatic disease and certain cancers, continues to rise worldwide. Paradoxically, despite an increasingly obesogenic environment, particularly in Western societies, undernutrition is also extremely common. The application of novel, sophisticated techniques, particularly related to imaging and molecular biology, has substantially advanced our understanding of the mechanisms controlling appetite and energy intake. This has led to a redefinition of many concepts, including the relative importance of central versus peripheral mechanisms, recognising that the gastrointestinal (GI) tract, particularly gut hormones, plays a critical role. Given the major advance in knowledge in the field, this Special Issue provides a comprehensive overview of the GI mechanisms underlying the regulation of appetite and energy intake, as a series of definitive reviews by international authorities. The reviews address gut-related mechanisms, including nutrient sensing, gut hormones and GI motility, gut-brain communication, including the roles of the vagus and the modulation of reward perception, the roles of diet and the microbiota, as well as the abnormalities associated with eating disorders, specifically obesity and anorexia of ageing, and the beneficial effects of bariatric surgery. The reviews cover both preclinical research and studies in humans, and are complemented by a number of important original papers.Medicinebicssclixisenatideintragastric meal retentionenergy intaketype 2 diabetesobesityamino acidisoleucinechronic supplementationenergy expenditureoral glucose tolerance testglycaemic controlgastric emptying breath testendocannabinoidcannabinoid CB1 receptorgut-brainintestinewestern dietpreferencewhey proteingastric emptyingappetitelifecoursegut hormoneshungerproteinTAS2R5TAS2R39TAS2R14agonistfood intakeGLP1CCKPYYminiature pigpig modelfunctional brain imagingmolecular imagingvagal afferentssingle fiber recordinginsulin resistanceGLP-1rgastric barostatscintigraphymeal ingestionpostprandial responseshedonic sensationshomeostatic sensationsabdominal wall activityabdominal distensiontastefatcarbohydratebariatric surgeryGLP-1ghrelinRoux-en-Y gastric bypassgastric bandsleeve gastrectomycircadiangastrointestinal tractenteroendocrine cellschemosensoryGIPnutrientshormonesfood ingestiondigestionsatietydigestive well-beingfunctional gastrointestinal disorderspostprandial symptomsbrainstemvagusfeedinggastrointestinalcue reactivitymeal anticipationmotivationnutrient preferenceflavoraversionbile acidsTGR-5FXRgastrointestinal hormonesbody weightgastric accommodationsatiationCB1 receptorgut-brainrewardagingwheyanorexiasupplementssarcopenianutrient sensingenteroendocrine cells (EECs)appetite regulationG-protein coupled receptors (GPCRs)bitter substancesgastric motor functionpostprandial blood glucosepreclinical studieshuman studiestextureoro-sensory exposuresensory sciencecephalic responsesbrain areasbrain stemweight managementintestinal brakeduodenal jejunal and ileal braketastantscircadian clockgastric bypass surgerymicrobiomehypothalamusMedicineFeinle-Bisset Christineedt1293627Horowitz MichaeledtFeinle-Bisset ChristineothHorowitz MichaelothBOOK9910557519503321Appetite and Satiety Control-Gut Mechanisms3022678UNINA