03959nam 2201081z- 450 991055749770332120231214133214.0(CKB)5400000000042854(oapen)https://directory.doabooks.org/handle/20.500.12854/76609(EXLCZ)99540000000004285420202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierProtein-Ligand Interactions: Target Identification and Drug DiscoveryBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (184 p.)3-0365-1050-8 3-0365-1051-6 Bioactive compounds and drugs are designed and screened on the basis of specific molecular targets as well as via the identification of active ingredients from traditional medicine or by serendipitous discovery. The development of novel therapeutic strategies not only requires a deep knowledge of the molecular processes and the cellular pathways involved in each pathological condition and disease, but also the specific protein targets and the effects of drug binding on protein conformation and activity. Understanding of how drugs can modify and modulate specific cellular pathways and functions will be helpful during the process of drug development and clinical trials.Protein—Ligand InteractionsProtein-Ligand InteractionsProtein–Ligand InteractionsResearch & information: generalbicsscChemistrybicsscserum half-life extensionfatty acid conjugationFcRn-mediated recyclingserum albumintranslocator protein (TSPO)CoCl2mitochondrial membrane potentialreactive oxygen species (ROS)cell viabilitycell deathlung cancer cell lineacetylcholinesteraseamyloid beta aggregationneuroprotectionmolecular dockingmulti-target drugstructure–activity relationshipbrassicasterolphytosterolsHSVMycobacterium tuberculosisHSV-1 DNA polymeraseHSV-1 TKhuman CDK2ACEUDP-galactopyranose mutaseheat shock protein 70Hsp70piperinefluorescence spectroscopymolecular dynamicsmolecular biophysicsGADD45βMKK7multiple myelomaprotein-ligand interactionSTD-NMRsigma receptorssigma ligandscancerSIGMAR1PGRMC1TMEM97NCI60 COMPARE analysismembranelipid-protein interactionlipid signallingkinase regulationphosphatidylinositolsmolecular docking simulationtarget identificationsmall-molecule derivatives of salicylanilidedrug discoverydrug developmentthyroid diseasesendocrine disruptor compoundhuman umbilical arteryvascular homeostasisResearch & information: generalChemistryAltieri Fabioedt1311497Altieri FabioothBOOK9910557497703321Protein-Ligand Interactions: Target Identification and Drug Discovery3030346UNINA