08897nam 2202653z- 450 991055749290332120231214132836.0(CKB)5400000000042902(oapen)https://directory.doabooks.org/handle/20.500.12854/68680(EXLCZ)99540000000004290220202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierPeptides for Health Benefits 2019Volume 2Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (342 p.)3-03936-084-1 3-03936-085-X In recent years, peptides have received increased interest from the pharmaceutical industry. The high potency, specificity, and safety profile are the main strengths of bioactive peptides as new and promising therapies that may fill the gap between small molecules and protein drugs. These positive attributes have renewed interest in the discovery, optimization, and development of peptides as pharmacological therapy. Among bioactive peptides, those released from food sources have acquired importance as nutraceutical and active components in functional foods because they possess regulatory functions that can lead to health benefits. This Special Issue covers a selection of recent research papers and reviews in the field of bioactive peptides. It covers all aspects of peptide research in relation to health promotion. In particular, it emphasizes current knowledge and research trends concerning bioactive peptides, including identification and quantification of peptides from new sources, methods for their production and purification, structure–function relationships, mechanisms of action, in vitro and in vivo assays for the evaluation of their bioactivity, physiological evidence to support health benefits, and peptide stability and bioavailability. Papers regarding the development of new drugs, functional foods, or nutraceuticals based on bioactive peptides were also considered.Peptides for Health Benefits 2019 Research & information: generalbicsscBiology, life sciencesbicsscantihypertensive peptidesfunctional foodfood-derivedfermentationChlorella sorokinianain silicoBIOPEP-UWM databaseproteomicsbioactive peptidesnano liquid chromatography tandem mass spectrometry (nanoLC-nanoESI MS/MS)apolipoprotein Eamyloid fibrilsAlzheimer's diseaseΑβ oligomeramyloidAβ peptidegliomaplateletsantiproliferative assayconjugationdocetaxeldoxorubicinextra domain BfibronectinFmoc/tBupeptide-drug conjugateprostate cancersolid-phase synthesistargetingacrylamideenteric nervous systemgalaninpigstomachformyl peptide receptorsligandsdiseasespolymicrobial biofilmsintragenic antimicrobial peptideHs02Pseudomonas aeruginosaStaphylococcus aureusosteostatinarthritisinflammationimmune responsecartilage destructionbone erosioncollagenhydrolysisenzymemolecular weightsheepskinNF-κBdry-cured pork hamangiotensin I converting enzymeendothelial dysfunctionmolecular blind dockingLactoferricin B (Lfcin B)Histatin-5antimicrobial peptides (AMPs)antifungal activityproteome microarraysynergytemporinMRSAantimicrobial peptidehuman keratinocytespseudin-2antisepsis, peptide antibioticsneurotensinasthmaT cellsIn situ tetramer stainingMHC tetramerantigen-specificconfocal microscopyfresh tissuevelvet antleralcalase hydrolysateantioxidant peptideprotection abilityoxidative stressCrassostrea angulatapidotimodCXCR3monocytemigrationPI3K/Akt pathwayT cellimmunomodulanthost defense peptidesmembrane activitycopperpiscidinsClostridioides difficileprolactin-releasing peptideGPR10RF-amide peptidesfood intake regulationenergy expenditureneuroprotectionsignalinggender differencesdyslipidemiaobesityhyperglycemiapulmonary emphysemaendothelial progenitor cellsangiogenic precursor cellspegylated glucagon-like peptide 1and endothelial regenerationmiiuy croaker (Miichthys miiuy)swim bladderFPYLRHantioxidant activitycytoprotective effectantimicrobial peptidesantimicrobial resistanceAMP identification and designbiosynthesismode of actionphysico-chemical propertiestherapeutic potentialinsectsCecropinsCec-analogsMDR infectious diseasesairway inflammationnon-atopic asthmahybrid peptidepro-inflammatory cytokinessPLA2MDAdatabaseproteolysisSMILES codefoodsnutritionchronic diseasesnutraceuticalspeptide vaccineimmune checkpoint inhibitorhumanized mousecancer antigenimmune suppressionvasoactive intestinal peptideVPAC1 receptorVPAC2 receptorrheumatic diseasesinflammatory bowel diseasecentral nervous system diseasestype 1 diabetesSjögren's syndromebiomarkershuman antimicrobial peptidesdefensinscathelicidinsanti-inflammatorypro-inflammatorypeptidecombinatorial librarylibrary designscreeningmutagenesisprolyl-hydroxyproline (Pro-Hyp)hydroxyprolyl-glycine (Hyp-Gly)collagen peptidefibroblastsfetal bovine serum (FBS)AMDCNVVEGFR1multimeric peptidesoral deliverycolorectal cancercancer stem cellschemopreventionbioactive peptidelunasinACE-inhibitory activitywhey peptidesmolecular dockinghypertensionantibiotic resistancecystic fibrosiscryptidesanti-biofilm peptidessynergistic effectsResearch & information: generalBiology, life sciencesHernández-Ledesma Blancaedt0Martínez-Villaluenga CristinaedtHernández-Ledesma BlancaothMartínez-Villaluenga CristinaothBOOK9910557492903321Peptides for Health Benefits 20193013216UNINA