07295nam 2202125z- 450 991055747630332120231214133155.0(CKB)5400000000043034(oapen)https://directory.doabooks.org/handle/20.500.12854/69198(EXLCZ)99540000000004303420202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRole of Natural Bioactive Compounds in the Rise and Fall of CancersVolume 2Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (318 p.)3-03943-292-3 3-03943-293-1 Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.Role of Natural Bioactive Compounds in the Rise and Fall of Cancers Research & information: generalbicsscBiology, life sciencesbicsscberberinesignaling pathwaysoncogenic cascadesTRAILmicroRNAscancer therapycolon cancer cellsethanolNrf2HO-1ER stressautophagyMMPsformononetincancerpreclinical modelscell signalingangiogenesisnobiletincolorectal cancerchemopreventionbioactivitiesexperimental therapeuticsHDACmultiple myelomaoleaceinbreast cancerpersistent organic pollutantsbreast cancer riskbreast cancer prognosticsystematic reviewcarrageenaninvasionmetastasisRacGAP1radiotherapymarine spongenatural productanticancer drugoral cancer inhibitionphytochemicalssmall organic agentsPiper eriopodon, alkenylphenolshuman cancer cellscell deathapoptosiscaspase-independent cell deathXIAP antagonistsXIAP-BIR3 domainCalocedrus formosanalung canceryateincell-cycle arrestxenograftisorhamnetinG2/M arrestROSAMPKpancreatic cancerepigallocatechin-3-gallate (EGCG)gemcitabineglycolysisphosphofructokinasenatural polyphenolsanticancer activitiesmolecular mechanismsStreptomycesmangroveanti-proliferativecolon cancerepithelial mesenchymal transitioninflammationmalignant cancernatural anti-inflammatory compoundspro-resolving lipidsanticancer drugsflavonoidsnatural compoundsXenopus laevisAOM/DSS modelmelanoma cellsnicotineα9-nAChRPD-L1STAT3gigantolAKTJAK/STATcancer stem celltumor maintenancetumor densityproteomicshonokiolanticancermechanismsignalling pathwayuterine sarcomafucoidanisobolographycolchicine alkaloidmesoporous silica nanoparticlestargeted delivery systemPD-1 immune checkpoint inhibitor and cancer immunotherapyglucose transportdrugsinnate immunityβ-glucansnutritionimmunotherapyestrogenestrogen receptor alphapolyphenolsdaidzeindaidzein metabolitespaclitaxelbreast cancer cellsobesityrenin-angiotensin systemeicosapentaenoic acidadipocyte inflammationolive leaf extractoleuropeinSeahorse analysiscancer metabolismglycolytic markersMalva pseudolavatera Webb &ampBerthel.acute myeloid leukemiareactive oxygen speciesbrain cancergliomasschwannomasmalignant tumors of the peripheral nerve sheath (MPNST)neurofibromasbioavailabilitynanoparticle-based delivery systemsnatural bioactive compoundgallic acidEGFR signalingp53EGCGnon-coding RNAsanti-cancer drugNSCLCEGFR TKIFASN inhibitorsresistanceResearch & information: generalBiology, life sciencesLuparello Claudioedt1291782Luparello ClaudioothBOOK9910557476303321Role of Natural Bioactive Compounds in the Rise and Fall of Cancers3021915UNINA