07336nam 2202149z- 450 991055747630332120210501(CKB)5400000000043034(oapen)https://directory.doabooks.org/handle/20.500.12854/69198(oapen)doab69198(EXLCZ)99540000000004303420202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRole of Natural Bioactive Compounds in the Rise and Fall of CancersVolume 2Basel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (318 p.)3-03943-292-3 3-03943-293-1 Recent years have seen the idea of a close association between nutrition and the modulation of cancer development/progression reinforced. An increasing amount of experimental and epidemiological evidence has been produced supporting the concept that many different bioactive components of food (e.g. polyphenols, mono- and polyunsaturated fatty acids, methyl-group donors, etc.) may be implicated in either the promotion of or the protection against carcinogenesis. At the cellular level, such compounds can have an impact on different but sometimes intertwined processes, such as growth and differentiation, DNA repair, programmed cell death, and oxidative stress. In addition, compelling evidence is starting to build up of the existence of primary epigenetic targets of dietary compounds, such as oncogenic/oncosuppressor miRNAs or DNA-modifying enzymes, which in turn impair gene expression and function. Since there is a growing interest in the study of the biochemical and molecular role played by food components and its impact on cellular processes and/or gene expressions directed towards the fine-tuning of cancer phenotypes, in this Special Issue researchers contributed with either research or review articles presenting the latest findings on the intracellular pathways and mechanisms affected by natural bioactive dietary molecules.Role of Natural Bioactive Compounds in the Rise and Fall of Cancers Biology, life sciencesbicsscResearch and information: generalbicsscacute myeloid leukemiaadipocyte inflammationAKTAMPKangiogenesisanti-cancer druganti-proliferativeanticanceranticancer activitiesanticancer druganticancer drugsAOM/DSS modelapoptosisautophagyberberineBerthel.bioactivitiesbioavailabilitybrain cancerbreast cancerbreast cancer cellsbreast cancer prognosticbreast cancer riskCalocedrus formosanacancercancer metabolismcancer stem cellcancer therapycarrageenancaspase-independent cell deathcell deathcell signalingcell-cycle arrestchemopreventioncolchicine alkaloidcolon cancercolon cancer cellscolorectal cancerdaidzeindaidzein metabolitesdrugsEGCGEGFR signalingEGFR TKIeicosapentaenoic acidepigallocatechin-3-gallate (EGCG)epithelial mesenchymal transitionER stressestrogenestrogen receptor alphaethanolexperimental therapeuticsFASN inhibitorsflavonoidsformononetinfucoidanG2/M arrestgallic acidgemcitabinegigantolgliomasglucose transportglycolysisglycolytic markersHDACHO-1honokiolhuman cancer cellsimmunotherapyinflammationinnate immunityinvasionisobolographyisorhamnetinJAK/STATlung cancermalignant cancermalignant tumors of the peripheral nerve sheath (MPNST)Malva pseudolavatera Webb &ampmangrovemarine spongemechanismmelanoma cellsmesoporous silica nanoparticlesmetastasismicroRNAsMMPsmolecular mechanismsmultiple myeloman/ananoparticle-based delivery systemsnatural anti-inflammatory compoundsnatural bioactive compoundnatural compoundsnatural polyphenolsnatural productneurofibromasnicotinenobiletinnon-coding RNAsNrf2NSCLCnutritionobesityoleaceinoleuropeinolive leaf extractoncogenic cascadesoral cancer inhibitionp53paclitaxelpancreatic cancerPD-1 immune checkpoint inhibitor and cancer immunotherapyPD-L1persistent organic pollutantsphosphofructokinasephytochemicalsPiper eriopodon, alkenylphenolspolyphenolspreclinical modelspro-resolving lipidsproteomicsRacGAP1radiotherapyreactive oxygen speciesrenin-angiotensin systemresistanceROSschwannomasSeahorse analysissignaling pathwayssignalling pathwaysmall organic agentsSTAT3Streptomycessystematic reviewtargeted delivery systemTRAILtumor densitytumor maintenanceuterine sarcomaxenograftXenopus laevisXIAP antagonistsXIAP-BIR3 domainyateinα9-nAChRβ-glucansBiology, life sciencesResearch and information: generalLuparello Claudioedt1291782Luparello ClaudioothBOOK9910557476303321Role of Natural Bioactive Compounds in the Rise and Fall of Cancers3021915UNINA