06337nam 2201777z- 450 991055744870332120231214133042.0(CKB)5400000000043253(oapen)https://directory.doabooks.org/handle/20.500.12854/68969(EXLCZ)99540000000004325320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierAntiviral AgentsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (386 p.)3-03928-953-5 3-03928-954-3 Antiviral agents are used for the treatment of viral diseases. Antiviral drugs have been successfully developed and used clinically for a limited number of important human viral diseases notably caused by human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV), herpes, and influenza viruses. Despite the successes of these antiviral drugs, issues with drug resistance and toxicity remain challenging. These challenges are driving research to identify new drug candidates and to investigate novel drug targets to develop new mechanistic drug classes. Antiviral agents are not available against many viruses that cause human disease and economic burdens; in particular, the development of antiviral agents against emerging, re-emerging, and neglected viruses is increasingly becoming a priority. This book includes six review articles that discuss new antiviral strategies. The reviews either discuss advances relating to a specific virus or new therapeutic targets and approaches. The book includes 15 original research articles reporting new antiviral agents against a variety of clinically and economically important viruses and studies into the prevalence or acquisition of drug resistance. Overall, this book is an exciting collection of new research and ideas relating to the development of antiviral agents.Research & information: generalbicsscBiology, life sciencesbicsscZika virusnucleoside analoguesantiviral agentsNS5prodrugsProTidesneural stem cellsRNA-dependent RNA polymerasecytomegaloviruslatent infectionTALENSurveyor nuclease mutation detection assayie-1 genequantitative real-time PCREpstein-Barr virusherpes viruseslytic gene expressionBurkitt lymphoma cellsclozapineantipsychotic drugantiviral drugenterovirusescoxsackievirus B4persistent infectionfluoxetineresistancemutationsherpes B virusmacacine herpesvirus-1genisteinflavonoidsacyclovirganciclovirPlantago asiaticaClerodendrum trichotomumRSVtherapeutic effectsacteosidehuman antimicrobial peptidesantiviral strategiesdefensinscathelicidinshepcidinstransferrinsinfluenza A virusbrevilin Aantiviralsesquiterpene lactonereplicationPRRSVpolyethyleniminePEIvirion internalizationendocytosisHIVpediatricsEthiopiapre-treatment drug resistancecombination antiretroviral therapy (cART)dried plasma spotsdried blood spotssphingolipidsglycosphingolipidsviruseslipid biosynthesisflavivirusJapanese encephalitis virusfurin inhibitorprecursor membrane proteinmeasles viruscentral nervous systemtropismtreatmentsporcine reproductive and respiratory syndrome virusginsenoside Rg1antiviral activitypro-inflammatory factorNF-κB signaling pathwayacute/latent infectioncongenital infectionantiviral agenttherapeutic strategiesnucleic acid-based therapeutic approachHCMV vaccineadoptive cell therapyRev response elementchemical footprintingSHAPEdrug discoverybranched peptidesherpesvirusimmediate-earlyIE1IE2ribozymeRNA interferenceCRISPR/Cassmall moleculeorthohantavirusphenyl-benzotriazolesC-FRAPorcine circovirus type 2epigallocatechin gallateheparan sulfateantiviral effectvirus attachmentmicrovirinlectinhuman immunodeficiency virushepatitis C virusantiviral inhibitornon-immunogenicviral entryprotein drugsLUMS1oleanane-type derivativesinfluenza A virus (IAV)virus entry inhibitorshemagglutinin (HA)Research & information: generalBiology, life sciencesAdamson Catherineedt1323411Adamson CatherineothBOOK9910557448703321Antiviral Agents3035519UNINA03270 am 2200589 n 450 991049581700332120240104030515.02-7351-2682-X10.4000/books.editionsmsh.18401(CKB)4100000010268605(FrMaCLE)OB-editionsmsh-18401(PPN)243134355(EXLCZ)99410000001026860520200220j|||||||| ||| 0freuu||||||m||||Du bidonville à l’hôpitalNouveaux enjeux de la maternité au RajasthanClémence JullienParisÉditions de la Maison des sciences de l’homme20201 online resource (396 p.) 2-7351-2501-7 Depuis les années 2000, la santé de la reproduction semble constituer un sujet d’inquiétude en Inde. Les taux de mortalité maternelle et infantile encore élevés discréditent l’image de superpuissance que l’État aime afficher, le déséquilibre du sex-ratio continue de se creuser et, malgré une importante baisse du taux de fécondité, le pays doit faire face à une population de plus d’un milliard trois cent millions d’habitants. À partir d’une enquête de terrain d’un an et demi dans un hôpital public et dans les bidonvilles de Jaipur, Clémence Jullien analyse les conséquences, pour les femmes et leur famille, des nouveaux programmes de santé : une prime financière incite les femmes à accoucher à l’hôpital plutôt qu’avec des accoucheuses traditionnelles et, depuis 2011, les soins obstétriques à l’hôpital sont devenus entièrement gratuits. Toutefois, ces programmes, censés garantir l’accès aux soins, rendent les bénéficiaires les plus vulnérables davantage conscients des inégalités socio-économiques qu’ils subissent, renforcent les stéréotypes existants et donnent au personnel hospitalier et aux membres d’ONG un pouvoir discrétionnaire. Tensions sociales (castes, classes) et religieuses se cristallisent autour de la maternité. D’autres enjeux cruciaux – discrimination à l’égard des petites filles, faible pouvoir décisionnel des femmes, recours limité à la contraception – surgissent alors, accentuant les différences au sein de la société indienne, sous couvert de progrès et au nom de l’intérêt de la nation.Social Sciences, BiomedicalIndeRajasthanmaternitéviolences obstétricalessex-ratiohôpitalONGmortalité infantilemortalité maternellesantésoinSocial Sciences, BiomedicalIndeRajasthanmaternitéviolences obstétricalessex-ratiohôpitalONGmortalité infantilemortalité maternellesantésoinJullien Clémence1348641Jeffery Roger1455064FR-FrMaCLEBOOK9910495817003321Du bidonville à l’hôpital3657106UNINA03608nam 2200625 450 991079115550332120230912131549.01-62788-205-7(OCoLC)893098157(OCoLC)ocn893098157(Au-PeEL)EBL5332238(CaPaEBR)ebr11535611(OCoLC)1030820066(Au-PeEL)EBL4968837(CaONFJC)MIL642348(OCoLC)1024276840(CaSebORM)9781592539611(MiAaPQ)EBC5332238(MiAaPQ)EBC4968837(EXLCZ)99255000000135235620180910d2014 uy 0engur|n|---|||||txtrdacontentcrdamediacrrdacarrierArchitecture and cityscapes /Gabriel Campanario1st editionBeverly, Massachusetts :Quarry Books,2014.1 online resource (112 p.) illThe urban sketching handbookAuthor's name from cover.1-59253-961-0 1-322-11097-2 Cover -- Title Page -- Contents -- About This Series -- Introduction -- KEYS -- I: Composition -- II: Scale -- III: Depth -- IV: Contrast -- V: Line -- VI: Creativity -- GALLERIES -- I: Pencil -- II: Pen -- III: Watercolor -- IV: Mixed Media -- Etiquette -- Challenges -- Contributors -- Acknowledgments -- About the Author.Award-winning illustrator Gabriel Campanario first introduced his approach to drawing in The Art of Urban Sketching, a showcase of more than 500 sketches and drawing tips shared by more than 100 urban sketchers around the world. Now, he drills down into specific challenges of making sketches on location, rain or shine, quickly or slowly, and the most suitable techniques for every situation, in The Urban Sketching Handbook series. It's easy to overlook that ample variety of buildings and spaces and the differences from city to city, country to country. From houses, apartments and shopping malls to public buildings and places of worship, the structures humans have created over the centuries, for shelter, commerce, industry, transportation or recreation, are fascinating subjects to study and sketch. In The Urban Sketching Handbook: Architecture and Cityscapes, Gabriel lays out keys to help make the experience of drawing architecture and cityscapes fun and rewarding. Using composition, depth, scale, contrast, line and creativity, sketching out buildings and structure has never been more inspirational. This guide will help you to develop your own creative approach, no matter what your skill level may be today. As much as The Urban Sketching Handbook: Architecture and Cityscapes may inspire you to draw more urban spaces, it can also help to increase your appreciation of the built environment. Drawing the places where we live, work and play, is a great way to show appreciation and creativity.Urban sketching handbook.Cities and towns in artArchitecture in artDrawingTechniqueNON-CLASSIFIABLEbisacshCities and towns in art.Architecture in art.DrawingTechnique.NON-CLASSIFIABLE.743.84NON000000bisacshCampanario Gabriel1563335MiAaPQMiAaPQMiAaPQBOOK9910791155503321Architecture and cityscapes3831665UNINA