02101nam 2200481z- 450 991055744770332120211118(CKB)5400000000043263(oapen)https://directory.doabooks.org/handle/20.500.12854/74201(oapen)doab74201(EXLCZ)99540000000004326320202111d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierIs Early Onset of Alcohol Use Associated with Later Alcohol Use?Frontiers Media SA20201 online resource (168 p.)2-88966-065-6 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contactNeurosciencesbicsscScience: general issuesbicsscadolescentsadultsalcoholearly onsetprenatalNeurosciencesScience: general issuesMarcos Pautassi Ricardoedt1328509Pilatti AngelinaedtJorge Bravo AdrianedtAcquas ElioedtMarcos Pautassi RicardoothPilatti AngelinaothJorge Bravo AdrianothAcquas ElioothBOOK9910557447703321Is Early Onset of Alcohol Use Associated with Later Alcohol Use3038628UNINA05076nam 2201477z- 450 991058594540332120220812(CKB)5600000000483023(oapen)https://directory.doabooks.org/handle/20.500.12854/91234(oapen)doab91234(EXLCZ)99560000000048302320202208d2022 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierTheme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug DiscoveryBaselMDPI - Multidisciplinary Digital Publishing Institute20221 online resource (360 p.)3-0365-4744-4 3-0365-4743-6 Nature continuously produces biologically useful molecules and provides humankind with life-saving drugs or therapies. Natural products (NPs) offer a vast, unique and fascinating chemical diversity and these molecules have evolved for optimal interactions with biological macromolecules. Moreover, natural products feature pharmacologically active pharmacophores which are pharmaceutically validated starting points for the development of new lead compounds. Over half of all approved (from 1981 to 2014) small-molecule drugs derived from NPs, including unaltered NPs, NPs synthetic derivatives and synthetic natural mimics, originated from a NPs pharmacophore or template. According to the FDA, NPs and their derivatives represent over one-third of all FDA-approved new drugs, in particular for anticancer/antibiotic lead compounds, which are remarkably enriched with NPs.Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th BirthdayChemistrybicsscOrganic chemistrybicsscResearch and information: generalbicsscampullosporinangiogenesisanti-tumor peptidesantibody engineeringanticanceranticancer activityantifungalantiproliferativeapoptosisapoptosis resistanceATG 4Bbiorthogonal chemistrybispecific antibodybotanical agentsbreast cancerbuteincancer stem cellscancer treatmentcaspase-3click chemistryco-culturecoronavirusCosmospora sp.COX inhibitorycytotoxiccytotoxic activityDARTSDecachaeta incomptademissidinedockingdrug resistanceECD-TDDFTelectron paramagnetic resonance (EPR) spectroscopyflavonoidsfrondoside-Afusidic acidglutamic acid methyl esterhepatocellular carcinomain vitro modelincomptine AinvasioniTRAQkaempferollung cancerMagnaporthe oryzaemarine fungimedicinal herbsmelanomaMERS-CoVmetabolomicsmetastasismolecular dockingmolecular networkingmulti-component reactionn/anatural productsophiobolin APCDpeptaibolsphytochemicalsphytopathogenpolygodialpregnancyproliferationRCE-4ROS productionSARS-CoVSARS-CoV-2Sepedonium ampullosporumsesquiterpene lactonesolanidane alkaloidssolanidinesolid-phase peptide synthesissoudanoneSparticola junciSrcSTAT3stemnesssteroidal alkaloidsstructure elucidationtarget identificationTEMPO-conjugatethe Bcl-2-Beclin 1 complexTrypsiligasetumor growthtumor heterogeneitytumor microenvironment (TME)viabilityviolaceinWittig reactionChemistryOrganic chemistryResearch and information: generalHussain Hidayatedt1302227Hussain HidayatothBOOK9910585945403321Theme Issue Honoring Prof. Dr. Ludger Wessjohann’s 60th Birthday: Natural Products in Modern Drug Discovery3026273UNINA