04553nam 2201273z- 450 991055743700332120231214133040.0(CKB)5400000000043353(oapen)https://directory.doabooks.org/handle/20.500.12854/69362(EXLCZ)99540000000004335320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRadiopharmaceuticals for PET Imaging - Issue ABasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 electronic resource (212 p.)3-03943-242-7 3-03943-243-5 Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.Medicinebicssckinetic analysisSiglec-9gallium-68vascular adhesion proteinVAP-1infectioninflammationosteomyelitisanimal modelStaphylococcus aureusmultiple myelomapositron emission tomography/computed tomographyradiopharmaceuticals18F-fluorodeoxyglucosetetrazine ligationPETSPECTindium-11fluorine-18positron emission tomography (PET), defluorinationisotopic exchangesilicon-based fluoride acceptorbioorthogonal chemistrytetrazineinverse electron-demand Diels-Alder ligationopioidnaloxoneoverdosefentanylcarfentanil[11C]carfentanilpositron emission tomographyreceptor occupancypharmacokinetics[18F]AlFNOTANODAGAPODSthiol-reactivelinkeraffibody moleculebioconjugationEGFRtumor imagingvulnerable plaquemolecular imagingPET imagingnanobodysingle-domain antibodysub-millimetre resolutionAlF-radiolabellingpreclinical radiopharmaceutical dosimetryimage-based internal dosimetryOLINDAMCT1/MCT4 lactate transporter inhibitor[18F]FACHradiation safetysigma-1 receptor availabilityorthotopic xenograft of glioblastoma in mousesmall animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI)(S)-(−)-[18F]fluspidineimaging-based biomarkerSV2A proteinPET radiotracerssynaptic lossradiochemistrypreclinical developmentclinical outcomesmonocarboxylate transporters (MCTs)FACH18F-labeled analog of FACHα-CCAblood-brain barrier (BBB)positron emission tomography (PET) imagingpeptidesproteolysismetabolic stabilityMedicineRoivainen Anneedt1323768Li Xiang-GuoedtRoivainen AnneothLi Xiang-GuoothBOOK9910557437003321Radiopharmaceuticals for PET Imaging - Issue A3035833UNINA