04570nam 2201285z- 450 991055743700332120210501(CKB)5400000000043353(oapen)https://directory.doabooks.org/handle/20.500.12854/69362(oapen)doab69362(EXLCZ)99540000000004335320202105d2020 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierRadiopharmaceuticals for PET Imaging - Issue ABasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20201 online resource (212 p.)3-03943-242-7 3-03943-243-5 Positron emission tomography (PET) is a very useful technique for medical diagnosis and drug development. Radiopharmaceuticals are a key element in PET techniques and one of the pivotal factors influencing the applications of PET. The aim of this Special Issue of Molecules is to report on the recent research work on a number of aspects of PET radiopharmaceuticals and their preclinical and clinical use. More specifically, the content of this Special Issue includes but is not limited to radiolabeling design, radiosynthesis, synthesis techniques, quality control methodologies, GMP production methods, product formulation, in vitro and in vivo preclinical PET evaluations, clinical evaluations, dosimetry, stability study and metabolite analysis, and modeling.Medicinebicssc(S)-(−)-[18F]fluspidine[11C]carfentanil[18F]AlF[18F]FACH18F-fluorodeoxyglucose18F-labeled analog of FACHaffibody moleculeAlF-radiolabellinganimal modelbioconjugationbioorthogonal chemistryblood-brain barrier (BBB)carfentanilclinical outcomesEGFRFACHfentanylfluorine-18gallium-68image-based internal dosimetryimaging-based biomarkerindium-11infectioninflammationinverse electron-demand Diels-Alder ligationisotopic exchangekinetic analysislinkerMCT1/MCT4 lactate transporter inhibitormetabolic stabilitymolecular imagingmonocarboxylate transporters (MCTs)multiple myelomanaloxonenanobodyNODAGANOTAOLINDAopioidorthotopic xenograft of glioblastoma in mouseosteomyelitisoverdosepeptidesPETPET imagingPET radiotracerspharmacokineticsPODSpositron emission tomographypositron emission tomography (PET) imagingpositron emission tomography (PET), defluorinationpositron emission tomography/computed tomographypreclinical developmentpreclinical radiopharmaceutical dosimetryproteolysisradiation safetyradiochemistryradiopharmaceuticalsreceptor occupancySiglec-9sigma-1 receptor availabilitysilicon-based fluoride acceptorsingle-domain antibodysmall animal Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI)SPECTStaphylococcus aureussub-millimetre resolutionSV2A proteinsynaptic losstetrazinetetrazine ligationthiol-reactivetumor imagingVAP-1vascular adhesion proteinvulnerable plaqueα-CCAMedicineRoivainen Anneedt1323768Li Xiang-GuoedtRoivainen AnneothLi Xiang-GuoothBOOK9910557437003321Radiopharmaceuticals for PET Imaging - Issue A3035833UNINA