03747nam 2201057z- 450 991055741400332120210501(CKB)5400000000043555(oapen)https://directory.doabooks.org/handle/20.500.12854/68513(oapen)doab68513(EXLCZ)99540000000004355520202105d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierFrom Basic Research to New Tools and Challenges for the Genotoxicity Testing of NanomaterialsBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (188 p.)3-0365-0112-6 3-0365-0113-4 This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage-the first step in carcinogenesis-must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.HumanitiesbicsscSocial interactionbicssc3D cultureadvanced in vitro modelAgNPAllium cepaaluminumantioxidant activityapoptosisBEAS-2B cells.CeO2NPcomet assaycytotoxiccytotoxicityDNA damageDNA methylationepigeneticsFPG enzymegenotoxicgenotoxicitygraphene oxideguthepatotoxicityHepG2high throughput screeningHprtHs27 human fibroblastshuman amniotic cellsin vitro genotoxicityin vitro testinglincomycinliverliver spheroidsmetal oxidesmetal/coating agent ratiomicronuclei formationmicronucleusmicronucleus assaymulti-walled carbon nanotubes (MWCNT)n/ananomaterialnanoparticlesnanoplasticsnanotoxicologynongenotoxic silver nanoparticlesoral routeoxidative stresspolystyrene nanoparticlesreduced graphene oxidesafer-by-designsilver ionsSiO2NPTiO2NPtitanium dioxide nanoparticlestritiated particlestungstenV79 cellsZnONPHumanitiesSocial interactionFESSARD Valérieedt1297531Nesslany FabriceedtFESSARD ValérieothNesslany FabriceothBOOK9910557414003321From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials3024504UNINA