01850nam0-22005771i-450 99000001600020331620240318130355.00-387-90138-80001600USA010001600(ALEPH)000001600USA01000160020000301d1965----|||y0itay0103----baengUS||||||||001yyReal and abstract analysisa modern treatment of the theory of functions of a real variableEdwin Hewitt, Karl StrombergNew YorkSpringerc1965X, 476 p.24 cmGraduate texts in mathematics250010003153472001Graduate texts in mathematics25Funzioni di variabile reale515HEWITT,Edwin41191STROMBERG,Karl41575990000016000203316515.8 HEW13283 Ing.515.8510 GTM 25 (A)0002643 CBS51000108945510 GTM 25 (B)0012741 CBS51000108946BKTECSCI20000914USA01170920000919USA01104620000919USA01151920001019USA01105320001019USA01145120001019USA01145820001019USA01153620001024USA01151120001027USA01151620001027USA01152020001110USA01170820001124USA011205ALANDI9020010622USA011522ALANDI9020010622USA011524PATTY9020011030USA01121220020403USA011609PATRY9020040406USA011603Real and abstract analysis79463UNISA05694nam 2201657z- 450 991055740910332120220111(CKB)5400000000043585(oapen)https://directory.doabooks.org/handle/20.500.12854/76747(oapen)doab76747(EXLCZ)99540000000004358520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSpumaretrovirusesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 online resource (352 p.)3-0365-0594-6 3-0365-0595-4 Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus-virus and virus-host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.Medicine and NursingbicsscNeurosciencesbicsscancient retrovirusesanimal experimentanimal modelANKRD17antiviral drugsantiviral host restrictionBFVBif1 (SH3GLB1)bovine foamy virusBrazilcatscell-free transmissioncGASchronic kidney diseasechronic renal diseaseco-evolutionco-infectionsco-speciationcomplete viral genomecross-species virus transmissioncytopathic effectELISAendogenous foamy virusendogenous retrovirusepidemiologyequine foamy virusEuropean bisonfallow deerfeline foamy virusfeline illnessfoamy virusfoamy virus vectorfoamy virus-host interactionsfoamy virusesfree-living primatesFV gene transfer to HSCsFV vectorsgene expressiongene markinggene therapygene therapy alternativesgibbonhematopoietic stem and progenitor cellshigh-throughput sequencingHSCimmune responsesin-vivo gene therapyinfectioninfectious cloneinnate immunityinnate sensingintegraseintegrationinter-species transmissionisolationJapankidneylatent infectionlesser apesmiRNA expressionmiRNA functionmiRNA target gene identificationmodel systemmountain lionneglected virusNeotropical primatesnew world primatesNHPparticle releasepathogenesispre-clinical canine modelproteaseproviral loadPuma concolorred deerreplication in vitroreplication kineticsreptile foamy virusresistancerestriction factorsretrovirusreverse transcriptasereverse transcriptase activityreverse transcriptionRNase Hroe deerSCID-X1sero-epidemiologyseroreactivityserotypesimian foamy virussimian retrovirusspuma virusspumaretrovirusSpumaretrovirusspumavirusSTINGviral prevalenceviral tropismvirus replicationvirus-host-interactionwild ruminantszoonoseszoonosisMedicine and NursingNeurosciencesKhan Arifaedt1319383Löchelt MartinedtLindemann DirkedtKhan ArifaothLöchelt MartinothLindemann DirkothBOOK9910557409103321Spumaretroviruses3033856UNINA