05657nam 2201645z- 450 991055740910332120231214133347.0(CKB)5400000000043585(oapen)https://directory.doabooks.org/handle/20.500.12854/76747(EXLCZ)99540000000004358520202201d2021 |y 0engurmn|---annantxtrdacontentcrdamediacrrdacarrierSpumaretrovirusesBasel, SwitzerlandMDPI - Multidisciplinary Digital Publishing Institute20211 electronic resource (352 p.)3-0365-0594-6 3-0365-0595-4 Foamy viruses, currently referred to as spumaretroviruses, are the most ancient retroviruses as evidenced by traces of viral sequences dispersed in all vertebrate classes from fish to mammals. Additionally, infectious foamy viruses circulate in a variety of mammalian species including simian, bovine, equine, caprine, and feline. Foamy viruses have many unique features which led to the division of the retrovirus family into two subfamilies, the Orthoretrovirinae and Spumaretrovirinae. In vitro, foamy viruses have a broad host range and in vivo, human infections have been described due to cross-species transmission from infected nonhuman primates. Thus far, there are no reports of virus-induced disease in humans or in the natural host species. These unique properties of foamy viruses have led researchers to develop foamy viruses as gene therapy vectors to study virus–virus and virus–host interactions for identifying factors involved in virus replication, transmission, and immune regulation that could influence potential clinical outcomes in humans as well as for using endogenous foamy virus sequences in the analysis of host species evolution.MedicinebicsscNeurosciencesbicsscspumavirusfeline illnessproviral loadneglected virusbovine foamy virusinfectious cloneparticle releasecell-free transmissionfoamy virusspumaretroviruscross-species virus transmissionzoonosisrestriction factorsimmune responsesFV vectorsvirus replicationlatent infectionfeline foamy virusepidemiologyretrovirusSpumaretrovirusmountain lionPuma concolorELISAproteasereverse transcriptaseRNase Hreverse transcriptionantiviral drugsresistancesimian foamy virusgibbonlesser apesco-evolutioncomplete viral genomeequine foamy virusisolationJapansero-epidemiologyreptile foamy virusendogenous foamy virusendogenous retrovirusancient retrovirusesco-speciationfoamy virus-host interactionsviral tropisminfectionkidneycatschronic kidney diseasechronic renal diseaseintegraseintegrationco-infectionsNHPpathogenesiszoonosesviral prevalenceNeotropical primatesfree-living primatesBrazilnew world primatessimian retrovirusBFVspuma virusmodel systemanimal modelanimal experimentmiRNA functiongene expressionantiviral host restrictiongene therapyin-vivo gene therapyhematopoietic stem and progenitor cellsfoamy virus vectorpre-clinical canine modelSCID-X1innate sensingcGASSTINGfoamy viruseswild ruminantsEuropean bisonred deerroe deerfallow deerseroreactivityinter-species transmissionHSCgene markingFV gene transfer to HSCsgene therapy alternativesserotypehigh-throughput sequencingreplication kineticscytopathic effectreverse transcriptase activitymiRNA expressionvirus-host-interactionmiRNA target gene identificationinnate immunityANKRD17Bif1 (SH3GLB1)replication in vitroMedicineNeurosciencesKhan Arifaedt1319383Löchelt MartinedtLindemann DirkedtKhan ArifaothLöchelt MartinothLindemann DirkothBOOK9910557409103321Spumaretroviruses3033856UNINA